G-protein-coupled receptors (GPCRs) mediate most of our physiological responses to hormones, neurotransmitters and environmental stimulants, and so have great potential as …
G-protein-coupled receptors have a major role in transmembrane signalling in most eukaryotes and many are important drug targets. Here we report the 2.7 Å resolution crystal …
U Gether - Endocrine reviews, 2000 - academic.oup.com
G protein-coupled, seven-transmembrane segment receptors (GPCRs or 7TM receptors), with more than 1000 different members, comprise the largest superfamily of proteins in the …
R Seifert, K Wenzel-Seifert - Naunyn-Schmiedeberg's archives of …, 2002 - Springer
The aim of this review is to provide a systematic overview on constitutively active G-protein- coupled receptors (GPCRs), a rapidly evolving area in signal transduction research. We will …
TE Hebert, S Moffett, JP Morello, TP Loisel… - Journal of Biological …, 1996 - ASBMB
One of the assumptions of the mobile receptor hypothesis as it relates to G protein-coupled receptors is that the stoichiometry of receptor, G protein, and effector is 1: 1: 1 (Bourne, HR …
S Hassan, Y Karpova, D Baiz, D Yancey… - The Journal of …, 2013 - Am Soc Clin Investig
Behavioral stress is known to promote tumor progression in experimental models, but the role of behavioral stress in cancer initiation is less clear. In this issue, Hassan et al. focus on …
P Leff - Trends in pharmacological sciences, 1995 - cell.com
Over the past few years, the concept that the activation of G protein-coupled receptors and transmitter-gated ion channels depends on a conformational change has received …
C Hoffmann, MR Leitz, S Oberdorf-Maass… - Naunyn-Schmiedeberg's …, 2004 - Springer
Although many β 1-receptor antagonists and β 2-receptor agonists have been used in pharmacotherapy for many years their pharmacological properties at all three known …
AW Kahsai, K Xiao, S Rajagopal, S Ahn… - Nature chemical …, 2011 - nature.com
Abstract Seven-transmembrane receptors (7TMRs), also called G protein–coupled receptors (GPCRs), represent the largest class of drug targets, and they can signal through several …