To understand brain function, it is essential that we discover how cellular signaling specifies
normal and pathological brain function. In this regard, chemogenetic technologies represent …

G-protein-coupled receptors (GPCRs) mediate most of our physiological responses to
hormones, neurotransmitters and environmental stimulants, and so have great potential as …

G-protein-coupled receptors have a major role in transmembrane signalling in most
eukaryotes and many are important drug targets. Here we report the 2.7 Å resolution crystal …

G protein-coupled, seven-transmembrane segment receptors (GPCRs or 7TM receptors),
with more than 1000 different members, comprise the largest superfamily of proteins in the …

The aim of this review is to provide a systematic overview on constitutively active G-protein-
coupled receptors (GPCRs), a rapidly evolving area in signal transduction research. We will …

One of the assumptions of the mobile receptor hypothesis as it relates to G protein-coupled
receptors is that the stoichiometry of receptor, G protein, and effector is 1: 1: 1 (Bourne, HR …

Behavioral stress is known to promote tumor progression in experimental models, but the
role of behavioral stress in cancer initiation is less clear. In this issue, Hassan et al. focus on …

Over the past few years, the concept that the activation of G protein-coupled receptors and
transmitter-gated ion channels depends on a conformational change has received …

Although many β 1-receptor antagonists and β 2-receptor agonists have been used in
pharmacotherapy for many years their pharmacological properties at all three known …

Abstract Seven-transmembrane receptors (7TMRs), also called G protein–coupled receptors
(GPCRs), represent the largest class of drug targets, and they can signal through several …