Large-area interfaces for single-molecule label-free bioelectronic detection

E Macchia, F Torricelli, P Bollella, L Sarcina… - Chemical …, 2022 - ACS Publications
Bioelectronic transducing surfaces that are nanometric in size have been the main route to
detect single molecules. Though enabling the study of rarer events, such methodologies are …

Molecular physiology of membrane guanylyl cyclase receptors

M Kuhn - Physiological reviews, 2016 - journals.physiology.org
Abstract cGMP controls many cellular functions ranging from growth, viability, and
differentiation to contractility, secretion, and ion transport. The mammalian genome encodes …

A Single‐Molecule Bioelectronic Portable Array for Early Diagnosis of Pancreatic Cancer Precursors

E Genco, F Modena, L Sarcina, K Björkström… - Advanced …, 2023 - Wiley Online Library
A cohort of 47 patients is screened for pancreatic cancer precursors with a portable 96‐well
bioelectronic sensing‐array for single‐molecule assay in cysts fluid and blood plasma …

The 2021 flexible and printed electronics roadmap

Y Bonnassieux, CJ Brabec, Y Cao… - Flexible and printed …, 2021 - iopscience.iop.org
This roadmap includes the perspectives and visions of leading researchers in the key areas
of flexible and printable electronics. The covered topics are broadly organized by the device …

Single-molecule detection with a millimetre-sized transistor

E Macchia, K Manoli, B Holzer, C Di Franco… - Nature …, 2018 - nature.com
Label-free single-molecule detection has been achieved so far by funnelling a large number
of ligands into a sequence of single-binding events with few recognition elements host on …

Sperm navigation along helical paths in 3D chemoattractant landscapes

JF Jikeli, L Alvarez, BM Friedrich, LG Wilson… - Nature …, 2015 - nature.com
Sperm require a sense of direction to locate the egg for fertilization. They follow gradients of
chemical and physical cues provided by the egg or the oviduct. However, the principles …

Controlling fertilization and cAMP signaling in sperm by optogenetics

V Jansen, L Alvarez, M Balbach, T Strünker… - Elife, 2015 - elifesciences.org
Optogenetics is a powerful technique to control cellular activity by light. The light-gated
Channelrhodopsin has been widely used to study and manipulate neuronal activity in vivo …

The C at S per channel controls chemosensation in sea urchin sperm

R Seifert, M Flick, W Bönigk, L Alvarez… - The EMBO …, 2015 - embopress.org
Sperm guidance is controlled by chemical and physical cues. In many species, Ca2+ bursts
in the flagellum govern navigation to the egg. In Arbacia punctulata, a model system of …

A stable physisorbed layer of packed capture antibodies for high-performance sensing applications

L Sarcina, C Scandurra, C Di Franco… - Journal of Materials …, 2023 - pubs.rsc.org
Antibody physisorption at a solid interface is a very interesting phenomenon that has
important effects on applications such as the development of novel biomaterials and the …

Sperm sensory signaling

D Wachten, JF Jikeli, UB Kaupp - Cold Spring Harbor …, 2017 - cshperspectives.cshlp.org
Fertilization is exceptionally complex and, depending on the species, happens in entirely
different environments. External fertilizers in aquatic habitats, like marine invertebrates or …