Single‐domain antibodies (sdAbs), the autonomous variable domains of camelid and shark
heavy‐chain antibodies, have many desirable properties as components of biologic drugs …

Antibodies are key reagents to investigate cellular processes. The development of
recombinant antibodies and binders derived from natural protein scaffolds has expanded …

Nanobodies are the recombinant antigen-recognizing domains of the minimalistic heavy
chain-only antibodies produced by camels and llamas. Nanobodies can be easily …

Antibodies commonly contain hydrophobic residues within their complementarity-
determining regions (CDRs) that mediate binding to target antigens. Unfortunately …

High‐affinity antibodies are critical for numerous diagnostic and therapeutic applications, yet
their utility is limited by their variable propensity to aggregate either at low concentrations for …

We identified 1219 articles published in 2006 that described work performed using
commercial optical biosensor platforms. It is interesting to witness how the biosensor market …

Developmental biology research would benefit greatly from tools that enable protein function
to be regulated, both systematically and in a precise spatial and temporal manner, in vivo. In …

In the past two decades, the emergence of coronavirus diseases has been dire distress on
both continental and global fronts and has resulted in the search for potent treatment …

In antibody development and manufacturing, protein aggregation is a common challenge
that can lead to serious efficacy and safety issues. To mitigate this problem, it is important to …

When panned with a transient heat denaturation approach against target enzymes, a human
VH (antibody heavy chain variable domain) phage display library yielded VHs with …