Financial Disclosure Ernst Lengyel disclosed that money was paid to his institution from
AbbVie (funding preclinical studies), NCI (RO1 grants), and the Ovarian Cancer Research …

Nearly 3% of the population carries genetic variants that lead to conditions that include
hereditary breast and ovarian cancer and Lynch syndrome. These pathogenic variants …

PURPOSE Germline testing (GT) is a central feature of prostate cancer (PCA) treatment,
management, and hereditary cancer assessment. Critical needs include optimized …

Women with germline mutations in the cancer susceptibility genes, BRCA1 or BRCA2,
associated with Hereditary Breast & Ovarian Cancer syndrome, have up to an 85% lifetime …

Background The cost-effectiveness of population-based panel testing for high-and moderate-
penetrance ovarian cancer (OC)/breast cancer (BC) gene mutations is unknown. We …

Early detection of breast cancer through screening reduces breast cancer mortality. The
benefits of screening must also be considered within the context of potential harms (eg, false …

Genetic testing for prostate cancer is rapidly growing and is increasingly being driven by
precision medicine. Rates of germline pathogenic variants have been reported in up to 15 …

Telegenetics—genetic counseling via live videoconferencing—can improve access to
cancer genetic counseling (CGC) in underserved areas, but studies on cancer telegenetics …

Objectives To provide recommendations for the selection of comparators for randomized
controlled trials of health-related behavioral interventions. Study Design and Setting The …

Cascade screening is the process of contacting relatives of people who have been
diagnosed with certain hereditary conditions. Its purpose is to identify, inform, and manage …