Idiopathic or “unexplained” infertility represents as many as 30% of infertility cases
worldwide. Conception, implantation, and term delivery of developmentally healthy infants …

During prophase of the first meiotic division, cells deliberately break their DNA. These DNA
breaks are repaired by homologous recombination, which facilitates proper chromosome …

Highlights•Dissolution by BLM-TopoIIIα-RMI1–RMI2 leads to non-crossovers only.•Unbiased
resolution by GEN1, MUS81 and SLX1 leads to crossovers and non-crossovers.•MLH1 …

Mlh1-Mlh3 is an endonuclease hypothesized to act in meiosis to resolve double Holliday
junctions into crossovers. It also plays a minor role in eukaryotic DNA mismatch repair …

Background Recent findings demonstrate that single nucleotide variants can cause non‐
obstructive azoospermia (NOA). In contrast, copy number variants (CNVs) were only …

DNA mismatch repair (MMR) plays a critical role in the maintenance of genetic integrity. The
failure of MMR in sperm DNA was found in male infertility. However, its aetiology in …

Purpose MLH3, a MutL homolog protein in mammals playing a role in DNA mismatch repair,
is associated with spermatogenesis and male infertility. The purpose of the present study …

Background Signaling molecules such as cytokines regulate spermatogenesis during the
maturation of germ cells and sperm apoptosis. Tumor necrosis factor alpha (TNFα) is one of …

DNA mismatch repair (MMR) is one of the biological pathways, which plays a critical role in
DNA homeostasis, primarily by repairing base-pair mismatches and insertion/deletion loops …

Background: Tumor necrosis factor-alpha (TNF-α) is a multifunctional cytokine that regulates
different cellular activities related to spermatogenesis. Tumor necrosis factor-alpha receptor …