The oxytocin receptor: from intracellular signaling to behavior
B Jurek, ID Neumann - Physiological reviews, 2018 - journals.physiology.org
The many facets of the oxytocin (OXT) system of the brain and periphery elicited nearly
25,000 publications since 1930 (see, as listed in PubMed), which revealed central roles for …
25,000 publications since 1930 (see, as listed in PubMed), which revealed central roles for …
Public health burden and epidemiology of atopic dermatitis
JI Silverberg - Dermatologic clinics, 2017 - derm.theclinics.com
AD is a chronic inflammatory skin disease affecting both children and adults. AD is
associated with a substantial public health burden secondary to high prevalence in many …
associated with a substantial public health burden secondary to high prevalence in many …
Two phase 3 trials of dupilumab versus placebo in atopic dermatitis
EL Simpson, T Bieber, E Guttman-Yassky… - … England Journal of …, 2016 - Mass Medical Soc
Background Dupilumab, a human monoclonal antibody against interleukin-4 receptor alpha,
inhibits signaling of interleukin-4 and interleukin-13, type 2 cytokines that may be important …
inhibits signaling of interleukin-4 and interleukin-13, type 2 cytokines that may be important …
Dupilumab with concomitant topical corticosteroid treatment in adults with atopic dermatitis with an inadequate response or intolerance to ciclosporin A or when this …
M de Bruin‐Weller, D Thaçi, CH Smith… - British Journal of …, 2018 - academic.oup.com
Background Atopic dermatitis is a chronic inflammatory skin disease that may require
systemic therapy. Ciclosporin A (CsA) is a widely used, potent immunosuppressant but it is …
systemic therapy. Ciclosporin A (CsA) is a widely used, potent immunosuppressant but it is …
Long-term management of moderate-to-severe atopic dermatitis with dupilumab and concomitant topical corticosteroids (LIBERTY AD CHRONOS): a 1-year …
A Blauvelt, M de Bruin-Weller, M Gooderham… - The Lancet, 2017 - thelancet.com
Background Dupilumab (an anti-interleukin-4-receptor-α monoclonal antibody) blocks
signalling of interleukin 4 and interleukin 13, type 2/Th2 cytokines implicated in numerous …
signalling of interleukin 4 and interleukin 13, type 2/Th2 cytokines implicated in numerous …
Efficacy and safety of dupilumab in adults with moderate-to-severe atopic dermatitis inadequately controlled by topical treatments: a randomised, placebo-controlled …
Background Data from early-stage studies suggested that interleukin (IL)-4 and IL-13 are
requisite drivers of atopic dermatitis, evidenced by marked improvement after treatment with …
requisite drivers of atopic dermatitis, evidenced by marked improvement after treatment with …
Guidelines of care for the management of atopic dermatitis: section 1. Diagnosis and assessment of atopic dermatitis
LF Eichenfield, WL Tom, SL Chamlin… - Journal of the American …, 2014 - Elsevier
Atopic dermatitis (AD) is a chronic, pruritic, inflammatory dermatosis that affects up to 25% of
children and 2% to 3% of adults. This guideline addresses important clinical questions that …
children and 2% to 3% of adults. This guideline addresses important clinical questions that …
[HTML][HTML] Emollient enhancement of the skin barrier from birth offers effective atopic dermatitis prevention
EL Simpson, JR Chalmers, JM Hanifin… - Journal of Allergy and …, 2014 - Elsevier
Background Atopic dermatitis (atopic eczema) is a chronic inflammatory skin disease that
has reached epidemic proportions in children worldwide and is increasing in prevalence …
has reached epidemic proportions in children worldwide and is increasing in prevalence …
Association of atopic dermatitis with depression, anxiety, and suicidal ideation in children and adults: a systematic review and meta-analysis
ATM Rønnstad, AS Halling-Overgaard… - Journal of the American …, 2018 - Elsevier
Background Atopic dermatitis (AD) has been associated with anxiety and depression, but
the magnitude of the alleged association is unknown. Objective To perform a systematic …
the magnitude of the alleged association is unknown. Objective To perform a systematic …
[HTML][HTML] Increasing comorbidities suggest that atopic dermatitis is a systemic disorder
PM Brunner, JI Silverberg, E Guttman-Yassky… - Journal of Investigative …, 2017 - Elsevier
Atopic dermatitis comorbidities extend well beyond the march to allergic conditions (food
allergy, asthma, allergic rhinitis, allergic conjunctivitis, and eosinophilic esophagitis) …
allergy, asthma, allergic rhinitis, allergic conjunctivitis, and eosinophilic esophagitis) …