Osteosarcoma is the most common primary bone sarcoma and is often diagnosed in the 2nd–
3rd decades of life. Response to the aggressive and highly toxic neoadjuvant methotrexate …

Considering the complexity of the current framework in oncology, the relevance of animal
models in biomedical research is critical in light of the capacity to produce valuable data with …

Ruminants are the only extant mammalian group possessing bony (osseous) headgear. We
obtained 221 transcriptomes from bovids and cervids and sequenced three genomes …

Osteosarcoma, an aggressive malignant cancer, has a high lung metastasis rate and lacks
therapeutic target. Here, we reported that chromobox homolog 4 (CBX4) was overexpressed …

Osteosarcoma (OS) is a rare, metastatic, human adolescent cancer that also occurs in pet
dogs. To define the genomic underpinnings of canine OS, we performed multi-platform …

Osteosarcoma (OS) is the most common malignant bone tumor in children. Despite efforts to
develop and implement new therapies, patient outcomes have not measurably improved …

Lineage commitment and tumorigenesis, traits distinguishing stem cells, have not been well
characterized and compared in mesenchymal stem cells derived from human dental pulp …

Osteosarcoma is a malignant primary tumor of bone, arising from transformed progenitor
cells with osteoblastic differentiation and osteoid production. While categorized as a rare …

While promising, immunotherapy has yet to be fully unlocked for the preponderance of
cancers where conventional chemoradiation reigns. This remains particularly evident in …

Osteosarcoma is a debilitating bone cancer that affects humans, especially children and
adolescents. A homologous form of osteosarcoma spontaneously occurs in dogs, and its …