[HTML][HTML] The lymphatic vasculature in the 21st century: novel functional roles in homeostasis and disease

G Oliver, J Kipnis, GJ Randolph, NL Harvey - Cell, 2020 - cell.com
Mammals have two specialized vascular circulatory systems: the blood vasculature and the
lymphatic vasculature. The lymphatic vasculature is a unidirectional conduit that returns …

Exercise training maintains cardiovascular health: signaling pathways involved and potential therapeutics

H Chen, C Chen, M Spanos, G Li, R Lu, Y Bei… - … and Targeted Therapy, 2022 - nature.com
Exercise training has been widely recognized as a healthy lifestyle as well as an effective
non-drug therapeutic strategy for cardiovascular diseases (CVD). Functional and …

A coalition to heal—the impact of the cardiac microenvironment

E Tzahor, S Dimmeler - Science, 2022 - science.org
Heart regenerative medicine has been gradually evolving from a view of the heart as a
nonregenerative organ with terminally differentiated cardiac muscle cells. Understanding the …

The evolving cardiac lymphatic vasculature in development, repair and regeneration

K Klaourakis, JM Vieira, PR Riley - Nature Reviews Cardiology, 2021 - nature.com
The lymphatic vasculature has an essential role in maintaining normal fluid balance in
tissues and modulating the inflammatory response to injury or pathogens. Disruption of …

Lymphatic vessel: origin, heterogeneity, biological functions, and therapeutic targets

Z Hu, X Zhao, Z Wu, B Qu, M Yuan, Y Xing… - … and Targeted Therapy, 2024 - nature.com
Lymphatic vessels, comprising the secondary circulatory system in human body, play a
multifaceted role in maintaining homeostasis among various tissues and organs. They are …

Lymphatic and immune cell cross-talk regulates cardiac recovery after experimental myocardial infarction

M Houssari, A Dumesnil, V Tardif, R Kivelä… - … , and vascular biology, 2020 - Am Heart Assoc
Objective: Lymphatics play an essential pathophysiological role in promoting fluid and
immune cell tissue clearance. Conversely, immune cells may influence lymphatic function …

Lymphatic endothelial cell junctions: molecular regulation in physiology and diseases

F Zhang, G Zarkada, S Yi, A Eichmann - Frontiers in physiology, 2020 - frontiersin.org
Lymphatic endothelial cells (LECs) lining lymphatic vessels develop specialized cell-cell
junctions that are crucial for the maintenance of vessel integrity and proper lymphatic …

Intercellular communication in the heart: therapeutic opportunities for cardiac ischemia

T Martins-Marques, DJ Hausenloy, JPG Sluijter… - Trends in molecular …, 2021 - cell.com
The maintenance of tissue, organ, and organism homeostasis relies on an intricate network
of players and mechanisms that assist in the different forms of cell–cell communication …

Clinical potential of adrenomedullin signaling in the cardiovascular system

L Bálint, NP Nelson-Maney, Y Tian, SD Serafin… - Circulation …, 2023 - Am Heart Assoc
Numerous clinical studies have revealed the utility of circulating AM (adrenomedullin) or MR-
proAM (mid-regional proAM 45-92) as an effective prognostic and diagnostic biomarker for a …

Role of Cardiac Lymphatics in Myocardial Edema and Fibrosis: JACC Review Topic of the Week

E Brakenhielm, A González, J Díez - Journal of the American College of …, 2020 - jacc.org
The cardiac lymphatic network plays a key role in regulation of myocardial extracellular
volume and immune cell homeostasis. In different pathological conditions cardiac …