Interferons are cytokines that have antiviral, antiproliferative and immunomodulatory effects.
Because of these important properties, in the past two decades, major research efforts have …

Members of the nuclear receptor superfamily of ligand-dependent transcription factors
regulate diverse aspects of immunity and inflammation by both positively and negatively …

Physical activity (PA) may modify the genetic effects that give rise to increased risk of
obesity. To identify adiposity loci whose effects are modified by PA, we performed genome …

Protein-DNA interactions (PDIs) mediate a broad range of functions essential for cellular
differentiation, function, and survival. However, it is still a daunting task to comprehensively …

The molecular pathways involved in the cellular response to interferon (IFN) γ have been the
focus of much research effort due to their importance in host defense against infection and …

The Cancer Genome Atlas (TCGA) project has generated gene expression data that divides
glioblastoma (GBM) into four transcriptional classes: proneural, neural, classical, and …

CCAAT enhancer-binding protein (C/EBP) β, C/EBPα, and peroxisome proliferator activated
receptor (PPAR) γ act in a cascade where C/EBPβ activates expression of C/EBPα and …

Monocytes express 1α‐hydroxylase, the enzyme responsible for final hydroxylation of
vitamin D3, in response to IFNγ and CD14/TLR4 activation. Cross‐talk between the JAK …

Innate immune responses to bacterial or viral infection require rapid transition of large
cohorts of inflammatory response genes from poised/repressed to actively transcribed …

Autophagy is a major innate immune defense pathway in both plants and animals. In
mammals, this cascade can be elicited by cytokines (IFN-γ) or pattern recognition receptors …