Malaria is a global infectious disease that remains a leading cause of morbidity and mortality
in the developing world. Multiple environmental and host and parasite factors govern the …

Quinoxaline 1, 4-di-N-oxides (QdNOs) have manifold biological properties, including
antimicrobial, antitumoral, antitrypanosomal and antiinflammatory/antioxidant activities …

Circadian clocks coordinate mammalian behavior and physiology enabling organisms to
anticipate 24-hour cycles. Transcription-translation feedback loops are thought to drive …

Intracellular pathogens mobilize host signaling pathways of their host cell to promote their
own survival. Evidence is emerging that signal transduction elements are activated in a …

Abstract Catalase (CAT), glutathione peroxidase (GPx) and Prx2 (peroxiredoxin 2) are the
main antioxidant enzymatic defenses of erythrocytes. They prevent and minimize oxidative …

Peroxiredoxin 2 (Prdx2) is the third most abundant erythrocyte protein. It was known
previously as calpromotin since its binding to the membrane stimulates the calcium …

Intracellular human pathogens are the deadliest infectious diseases and pose great difficulty
to effectively treat due to their protection inside the host cell and the development of …

STUDY QUESTION Are all components of the peroxiredoxins (PRDXs) system important to
control the levels of reactive oxygen species (ROS) to maintain viability and DNA integrity in …

N-Oxides of heterocyclic compounds are the focus of medical chemistry due to their diverse
biological properties. The high reactivity and tendency to undergo various rearrangements …

With half of the world's population at risk for malaria infection and with drug resistance on the
rise, the search for mutation-resistant therapies has intensified. We report here a therapy for …