Large-conductance Ca2+-and voltage-activated K+ (BK) channels play many physiological
roles ranging from the maintenance of smooth muscle tone to hearing and neurosecretion …

The distal convoluted tubule is the nephron segment that lies immediately downstream of
the macula densa. Although short in length, the distal convoluted tubule plays a critical role …

A dietary potassium load induces a rapid kaliuresis and natriuresis, which may occur even
before plasma potassium and aldosterone (aldo) levels increase. Here we sought to gain …

Primary aldosteronism (PA) is an endocrinopathy characterized by dysregulated
aldosterone production that occurs despite suppression of renin and angiotensin II, and that …

Ca2+-and voltage-gated K+ channels of large conductance (BK channels) are expressed in
a diverse variety of both excitable and inexcitable cells, with functional properties …

Dietary potassium loading results in rapid kaliuresis, natriuresis, and diuresis associated
with reduced phosphorylation (p) of the distal tubule Na+-Cl− cotransporter (NCC) …

The World Health Organization ranks hypertension the leading global risk factor for disease,
specifically, cardiovascular disease. Blood pressure (BP) is higher in Westernized …

Slowpoke (Slo) potassium channels display extraordinarily high conductance, are
synergistically activated by a positive transmembrane potential and high intracellular Ca2+ …

BACKGROUND Although embryo implantation is a prerequisite for human reproduction, it
remains a poorly understood process. The molecular mechanisms regulating endometrial …

Dietary potassium (K+) intake has antihypertensive effects, prevents strokes, and improves
cardiovascular outcomes. The underlying mechanism for these beneficial effects of high K+ …