Oxidative stress is increasingly recognized as a central event contributing to the
degeneration of dopaminergic neurons in the pathogenesis of Parkinson's disease (PD) …

Propofol is an intravenous agent used commonly for the induction and maintenance of
anesthesia, procedural, and critical care sedation in children. The mechanisms of action on …

The mitochondrion is the most important organelle in determining continued cell survival
and cell death. Mitochondrial dysfunction leads to many human maladies, including …

Mitochondrial disease, once thought to be a rare clinical entity, is now recognized as an
important cause of a wide range of neurologic, cardiac, muscle, and endocrine disorders …

The mitochondrion is a vital component in cellular energy metabolism and intracellular
signaling processes. Mitochondria are involved in a myriad of complex signaling cascades …

Opinion statement While numerous treatments for mitochondrial disorders have been
suggested, relatively few have undergone controlled clinical trials. Treatment of these …

Mitochondrial dysfunction is considered one of the major causative factors in the aging
process, ischemia/reperfusion (I/R), septic shock, and neurodegenerative disorders like …

Cerebral cavernous malformations (CCM) are manifested by microvascular lesions
characterized by leaky endothelial cells with minimal intervening parenchyma …

Iron and calcium share the common feature of being essential for normal neuronal function.
Iron is required for mitochondrial function, synaptic plasticity, and the development of …

Melatonin prevents mitochondrial failure in models of sepsis through its ability to inhibit the
expression and activity of both cytosolic (iNOS) and mitochondrial (i‐mtNOS) inducible nitric …