Principles of odor coding in vertebrates and artificial chemosensory systems

I Manzini, D Schild, C Di Natale - Physiological reviews, 2022 - journals.physiology.org
The biological olfactory system is the sensory system responsible for the detection of the
chemical composition of the environment. Several attempts to mimic biological olfactory …

Signal detection and coding in the accessory olfactory system

J Mohrhardt, M Nagel, D Fleck, Y Ben-Shaul… - Chemical …, 2018 - academic.oup.com
In many mammalian species, the accessory olfactory system plays a central role in guiding
behavioral and physiological responses to social and reproductive interactions. Because of …

Hypoxia sensing requires H2S-dependent persulfidation of olfactory receptor 78

YJ Peng, J Nanduri, N Wang, GK Kumar… - Science …, 2023 - science.org
Oxygen (O2) sensing by the carotid body is critical for maintaining cardiorespiratory
homeostasis during hypoxia. Hydrogen sulfide (H2S) signaling is implicated in carotid body …

[HTML][HTML] Direct activation of microglia by β-glucosylceramide causes phagocytosis of neurons that exacerbates Gaucher disease

T Shimizu, CR Schutt, Y Izumi, N Tomiyasu, Z Omahdi… - Immunity, 2023 - cell.com
Gaucher disease (GD) is the most common lysosomal storage disease caused by recessive
mutations in the degrading enzyme of β-glucosylceramide (β-GlcCer). However, it remains …

[HTML][HTML] The role of transient receptor potential channels in metastasis

S Bai, Y Wei, R Liu, Y Chen, W Ma, M Wang… - Biomedicine & …, 2023 - Elsevier
Metastasis is the hallmark of failed tumor treatment and is typically associated with death
due to cancer. Transient receptor potential (TRP) channels affect changes in intracellular …

A 3D transcriptomics atlas of the mouse nose sheds light on the anatomical logic of smell

MLRT Segura, E Abou Moussa, E Garabello… - Cell Reports, 2022 - cell.com
The sense of smell helps us navigate the environment, but its molecular architecture and
underlying logic remain understudied. The spatial location of odorant receptor genes (Olfrs) …

The role of Olfr78 in the breathing circuit of mice

H Torres-Torrelo, P Ortega-Sáenz, D Macías, M Omura… - Nature, 2018 - nature.com
The carotid body is essential for the adaptation of mammals to environmental or pathological
conditions that result in hypoxaemia. In response to hypoxia, neuron-like oxygen-sensitive …

Central role of G protein Gαi2 and Gαi2+ vomeronasal neurons in balancing territorial and infant-directed aggression of male mice

AC Trouillet, M Keller, J Weiss… - Proceedings of the …, 2019 - National Acad Sciences
Aggression is controlled by the olfactory system in many animal species. In male mice,
territorial and infant-directed aggression are tightly regulated by the vomeronasal organ …

PhoDAGs enable optical control of diacylglycerol-sensitive transient receptor potential channels

T Leinders-Zufall, U Storch, K Bleymehl… - Cell Chemical …, 2018 - cell.com
Diacylglycerol-sensitive transient receptor potential (TRP) channels play crucial roles in a
wide variety of biological processes and systems, but their activation mechanism is not well …

Heme-based oxygen gasoreceptors

S Anbalagan - American Journal of Physiology …, 2024 - journals.physiology.org
To investigate gasocrine signaling, there is a critical need to identify gasoreceptors for the
essential gasotransmitters like O2. Based on existing scientific literature, I propose that …