Autophagy is a ubiquitous homeostatic mechanism for the degradation or turnover of cellular
components. Degradation of mitochondria via autophagy (mitophagy) is involved in a …

Eukaryotic cells engage in autophagy, an internal process of self-degradation through
lysosomes. Autophagy can be classified as selective or non-selective depending on the way …

Parkinson's disease (PD) is the second most common neurodegenerative disorder
worldwide, mainly affecting the elderly. The disease progresses gradually, with core motor …

The astronomical increase of the world's aged population is associated with the increased
prevalence of neurodegenerative diseases, heightened disability, and extremely high costs …

Macroautophagy (autophagy) delivers intracellular constituents to the lysosome to promote
catabolism. During development in multiple organisms, autophagy mediates various cellular …

Abstract Fine particulate matters (PM2. 5) increased the risk of pulmonary fibrosis. However,
the regulatory mechanisms of lung epithelium in pulmonary fibrosis remained elusive. Here …

The formation of autophagosomes and their fusion with lysosomes are key events that
underpin autophagic degradation of cargoes. The core ATG8 system, which consists of the …

Accounting for more than 70% of ovarian cancer cases, epithelial ovarian malignancy has a
low 5-year survival rate. MicroRNAs may be targeted in the clinical treatment of the disease …

Background F‐box and WD repeat domain containing 7 (FBXW7) is a critical tumor
suppressor. The expression of FBXW7 is decreased in oral squamous cell carcinoma …

Utilizing oxidative stress has recently been regarded as a potential strategy for tumor
therapy. The NUAK family SNF1-like kinase 1 (NUAK1) is a critical component of the …