Obesity reaches up to epidemic proportions globally and increases the risk for a wide
spectrum of co-morbidities, including type-2 diabetes mellitus (T2DM), hypertension …

Ononin is a naturally occurring isoflavone glycoside generally found in various plants like
soybeans, legumes, Chinese licorice, Mongolian milkvetch, kudzu, broccoli, and lupine. The …

Hepatic insulin resistance is recognized as a driver of type 2 diabetes and fatty liver disease
but specific therapies are lacking. Here we explore the potential of human induced …

A novel series of thiazole derivatives with pyrazole scaffold 16a-l as hybrid rosiglitazone/
celecoxib analogs was designed, synthesized and tested for its PPAR-γ activation, α …

The aim of the present study was to investigate the effect of etanercept (ETA)—an anti-tumor
necrosis factor α (TNF-α) monoclonal antibody—on metabolic disorders such as obesity …

Fetal programming occurs during the gestational age when exposure to environmental
stimuli can cause long-term changes in the fetus, predisposing it to develop chronic non …

Type 2 diabetes mellitus (T2DM), a prevalent chronic metabolic disorder, is closely linked to
persistent low-grade inflammation, significantly contributing to its development and …

Introduction It is suggested that cytokines play a key role in the pathogenesis of type 2
diabetes mellitus (T2DM). Therefore, this study explored two recently discovered cytokines …

Type 2 diabetes mellitus (T2DM) is a prevalent chronic condition, accounting for over 90% of
diabetes cases globally, characterized by insulin resistance and chronic hyperglycemia …

Systemic inflammation represents a shared pathophysiological mechanism which underlies
the frequent clinical associations among chronic inflammatory rheumatic diseases (CIRDs) …