The aims of severe perioperative bleeding management are three-fold. First, preoperative
identification by anamesis and laboratory testing of those patients for whom the …

Platelet inhibitors are the mainstay treatment for patients with vascular diseases. The current
'gold standard'antiplatelet agent clopidogrel has several pharmacological and clinical …

BACKGROUND The increased morbidity and mortality associated with coagulopathy and
thrombocytopenia after trauma are well described. However, few studies have assessed …

An increasing number of patients suffering from cardiovascular disease, especially coronary
artery disease (CAD), are treated with aspirin and/or clopidogrel for the prevention of major …

Background and objectives Clopidogrel non-responsiveness is associated with adverse
clinical outcome. We aimed to investigate whether individualized antiplatelet treatment in …

Individualised antiplatelet therapy and platelet function testing have attracted considerable
clinical interest, but several aspects of test performance have not been thoroughly …

Background: Prognostic values of genotyping and phenotyping for assessment of
clopidogrel responsiveness have been shown in independent studies. Objectives: To …

Trauma is the leading cause of death among people under the age of 44. Hemorrhage is a
major contributor to deaths related to trauma in the first 48 h. Accordingly, the management …

Congenital thrombotic thrombocytopenic purpura (TTP) is a very rare but potentially life-
threatening disorder. This phase I/II trial compared the pharmacokinetics and …

Background Antiplatelet (AP) medication use is common among trauma patients and is
associated with poor outcomes. Management options for platelet dysfunction in trauma …