Membrane-perturbing effect of fatty acids and lysolipids

A Arouri, OG Mouritsen - Progress in lipid research, 2013 - Elsevier
Due to their amphipathicity fatty acids and lysolipids incorporate into lipid membranes and
may hence exert an effect on membrane permeability, morphology, and stability. Several …

Prodrugs and nanomicelles to overcome ocular barriers for drug penetration

V Gote, M Ansong, D Pal - Expert Opinion on Drug Metabolism & …, 2020 - Taylor & Francis
Introduction Ocular barriers hinder drug delivery and reduce drug bioavailability. This article
focuses on enhancing drug absorption across the corneal and conjunctival epithelium. Both …

Stat3 controls cell death during mammary gland involution by regulating uptake of milk fat globules and lysosomal membrane permeabilization

TJ Sargeant, B Lloyd-Lewis, HK Resemann… - Nature cell …, 2014 - nature.com
We have previously demonstrated that Stat3 regulates lysosomal-mediated programmed
cell death (LM-PCD) during mouse mammary gland involution in vivo. However, the …

Lipids, curvature, and nano‐medicine

OG Mouritsen - European journal of lipid science and …, 2011 - Wiley Online Library
The physical properties of the lamellar lipid‐bilayer component of biological membranes are
controlled by a host of thermodynamic forces leading to overall tensionless bilayers with a …

Robust and tunable performance of a cell-free biosensor encapsulated in lipid vesicles

MA Boyd, W Thavarajah, JB Lucks, NP Kamat - Science advances, 2023 - science.org
Cell-free systems have enabled the development of genetically encoded biosensors to
detect a range of environmental and biological targets. Encapsulation of these systems in …

Recent experimental developments in studying passive membrane transport of drug molecules

M Sharifian Gh - Molecular Pharmaceutics, 2021 - ACS Publications
The ability to measure the passive membrane permeation of drug-like molecules is of
fundamental biological and pharmaceutical importance. Of significance, passive diffusion …

Fatty acids-modified liposomes for encapsulation of bioactive peptides: Fabrication, characterization, storage stability and in vitro release

R Huang, H Song, X Wang, H Shen, S Li, X Guan - Food Chemistry, 2024 - Elsevier
The fragile membranes of liposomes limit their application by the food industry. In this study,
we hypothesized that interactions between fatty acids with different chain lengths and …

Lipases, liposomes and lipid-prodrugs

A Arouri, AH Hansen, TE Rasmussen… - Current opinion in colloid …, 2013 - Elsevier
Colloidal and interfacial phenomena lie at the core of drug formulation, drug delivery, as well
as drug binding and action at diseased sites, eg, in cancer therapy. We review a class of …

Liposome-embedding silicon microparticle for oxaliplatin delivery in tumor chemotherapy

A Cevenini, C Celia, S Orrù, D Sarnataro, M Raia… - Pharmaceutics, 2020 - mdpi.com
Mesoporous silicon microparticles (MSMPs) can incorporate drug-carrying nanoparticles
(NPs) into their pores. An NP-loaded MSMP is a multistage vector (MSV) that forms a …

A liposomal fluorescence assay to study permeation kinetics of drug-like weak bases across the lipid bilayer

K Eyer, F Paech, F Schuler, P Kuhn, R Kissner… - Journal of Controlled …, 2014 - Elsevier
Lipid bilayer permeation is considered the major route for in vivo barrier passage of drugs.
Despite this fact, no technique is currently available to measure the kinetics of permeation …