Recent advances on human milk oligosaccharide antimicrobial activity

SK Spicer, JA Gaddy, SD Townsend - Current opinion in chemical biology, 2022 - Elsevier
Over the past century, human health has been enhanced by antimicrobial development.
Following the deployment of the first antibiotics in the 1940s, bacterial resistance evolved …

Synthesis as an expanding resource in human milk science

LL Xu, SD Townsend - Journal of the American Chemical Society, 2021 - ACS Publications
Few classes of natural products rival the structural audacity of oligosaccharides. Their
complexity, however, has stood as an immense roadblock to translational research, as …

Human Milk Oligosaccharides as Potential Antibiofilm Agents: A Review

A Bhowmik, P Chunhavacharatorn, S Bhargav… - Nutrients, 2022 - mdpi.com
Surface-associated bacterial communities called biofilms are ubiquitous in nature. Biofilms
are detrimental in medical settings due to their high tolerance to antibiotics and may alter the …

Antibiofilm Activity of Human Milk Oligosaccharides against Multidrug Resistant and Susceptible Isolates of Acinetobacter baumannii

SK Spicer, RE Moore, J Lu, MA Guevara… - ACS infectious …, 2021 - ACS Publications
Acinetobacter baumannii is a serious threat to human health, per the Centers for Disease
Control and Prevention's latest threat assessment. A. baumannii is a Gram-negative …

Beyond GalNAc! Drug delivery systems comprising complex oligosaccharides for targeted use of nucleic acid therapeutics

J O'Sullivan, J Muñoz-Muñoz, G Turnbull, N Sim… - RSC …, 2022 - pubs.rsc.org
Nucleic Acid Therapeutics (NATs) are establishing a leading role for the management and
treatment of genetic diseases following FDA approval of nusinersen, patisiran, and givosiran …

Understanding the pathways leading to gut dysbiosis and enteric environmental dysfunction in infants: the influence of maternal dysbiosis and other microbiota …

V Moya-Alvarez, PJ Sansonetti - FEMS Microbiology Reviews, 2022 - academic.oup.com
Maternal environmental enteric dysfunction (EED) encompasses undernutrition with an
inflammatory gut profile, a variable degree of dysbiosis and increased translocation of …

The Diverse Antimicrobial Activities of Human Milk Oligosaccharides against Group B Streptococcus

RE Moore, SD Townsend, JA Gaddy - ChemBioChem, 2022 - Wiley Online Library
Streptococcus agalactiae or Group B Streptococcus (GBS) is a Gram‐positive bacterial
pathobiont that is the etiological cause of severe perinatal infections. GBS can colonize the …

The Utility of Human Milk Oligosaccharides against Group B Streptococcus Infections of Reproductive Tissues and Cognate Adverse Pregnancy Outcomes

RE Moore, SK Spicer, J Lu, SA Chambers… - ACS Central …, 2023 - ACS Publications
Preterm birth affects nearly 10% of all pregnancies in the United States, with 40% of those
due, in part, to infections. Streptococcus agalactiae (Group B Streptococcus, GBS) is one of …

Anti‐biofilm Activity of Human Milk Oligosaccharides in Clinical Strains of Streptococcus agalactiae with Diverse Capsular and Sequence Types

RE Moore, SK Spicer, JA Talbert, SD Manning… - …, 2023 - Wiley Online Library
Abstract Group B Streptococcus (GBS) is an encapsulated Gram‐positive bacterial pathogen
that causes severe perinatal infections. Human milk oligosaccharides (HMOs) are short …

[HTML][HTML] Evaluation of Kochetkov Hemiaminal hydrolysis under acidic, alkaline, and neutral conditions

JA Talbert, SD Townsend - Carbohydrate Research, 2024 - Elsevier
The most common precursors to synthetic glycoproteins are reducing end glycosyl amines.
To afford these amines, a carbohydrate is reacted with an excess of an ammonia source to …