Hypertension is a frequent condition encountered during kidney disease development and a
leading cause in its progression. Hallmark factors contributing to hypertension constitute a …

The cellular mechanisms and signaling network that guide the cardiac disease
pathophysiology are inextricably intertwined, which explains the current scarcity of effective …

Aims Acute kidney injury (AKI) can limit the clinical use of cisplatin in cancer treatment. The
drivers of cisplatin-induced AKI include oxidative stress, mitochondrial dysfunction and …

Abstract Type 1 diabetes (T1D) is caused by the autoimmune destruction of pancreatic beta
cells. Pluripotent stem cells can now be differentiated into beta cells, thus raising the …

Background Renal interstitial fibrosis (RIF) is a common pathway for progression of chronic
kidney disease (CKD) to end-stage renal disease. In our previous study, it has been …

Background/Aims: Renalase, a novel flavoprotein expressed in the kidney and heart,
reduces renal tubular necrosis and apoptosis, which suggests that it might protect against …

Background Repeated administration of cisplatin causes CKD. In previous studies, we
reported that the kidney-secreted survival protein renalase (RNLS) and an agonist peptide …

Background An increased risk for developing essential hypertension, stroke and diabetes is
associated with single nucleotide gene polymorphisms in renalase, a newly described …

Renalase was discovered as a protein synthesized by the kidney and secreted in blood
where it circulates at a concentration of approximately 3–5 μg/ml. Initial reports suggested …

Acute pancreatitis is a disease associated with inflammation and tissue damage. One
protein that protects against acute injury, including ischemic injury to both the kidney and …