Genetic and epigenetic mechanisms of gene regulation during lens development

A Cvekl, MK Duncan - Progress in retinal and eye research, 2007 - Elsevier
Recent studies demonstrated a number of links between chromatin structure, gene
expression, extracellular signaling and cellular differentiation during lens development …

The human aquaporin gene family

B Yang - Current genomics, 2000 - ingentaconnect.com
Aquaporin (AQP) water channel proteins are responsible for osmotically driven water
transport across cell membranes of mammalian tissues, lower animals and plants. Recently …

Novel single-base deletional mutation in major intrinsic protein (MIP) in autosomal dominant cataract

DD Geyer, MA Spence, M Johannes, P Flodman… - American journal of …, 2006 - Elsevier
PURPOSE: To further elucidate the cataract phenotype, and identify the gene and mutation
for autosomal dominant cataract (ADC) in an American family of European descent (ADC2) …

Particle irradiation induces FGF2 expression in normal human lens cells

PY Chang, KA Bjornstad, E Chang… - Radiation …, 2000 - meridian.allenpress.com
Abstract Chang, PY, Bjornstad, KA, Chang, E., McNamara, M., Barcellos-Hoff, MH, Lin, SP,
Aragon, G., Polansky, JR, Lui, GM and Blakely, EA Particle Irradiation Induces FGF2 …

MIP/Aquaporin 0 Represents a Direct Transcriptional Target of PITX3 in the Developing Lens

EA Sorokina, S Muheisen, N Mlodik, EV Semina - PLoS One, 2011 - journals.plos.org
The PITX3 bicoid-type homeodomain transcription factor plays an important role in lens
development in vertebrates. PITX3 deficiency results in a spectrum of phenotypes from …

Effect of etoposide on grass pea DNA topoisomerase II: an in silico, in vivo, and in vitro assessments

A Samanta, TR Maity, S Das, AK Datta… - Bulletin of the National …, 2019 - Springer
Background Etoposide is one of the most potential anti-cancerous drugs that targets
topoisomerase II (topoII) and inhibits its activity by ligation with the DNA molecule. Results In …

Overlapping Sp1 and AP2 binding sites in a promoter element of the lens-specific MIP gene

C Ohtaka-Maruyama, X Wang, H Ge… - Nucleic acids …, 1998 - academic.oup.com
The MIP gene, the founder of the MIP family of channel proteins, is specifically expressed in
fiber cells of the ocular lens and expression is regulated temporally and spatially during …

Lens cell targetting for gene therapy of prevention of posterior capsule opacification

F Malecaze, NH Lubsen, B Serre, A Decha, M Duboue… - Gene therapy, 2006 - nature.com
Posterior capsule opacification is the main complication of cataract surgery. Using
adenovirus-mediated gene transfer, we recently reported that it was feasible to prevent PCO …

A new locus for autosomal dominant cataract on chromosome 12q13

JB Bateman, M Johannes, P Flodman… - … & visual science, 2000 - iovs.arvojournals.org
purpose. To map the gene for autosomal dominant cataracts (ADC) in an American white
family of European descent. methods. Ophthalmic examinations and linkage analyses using …

[HTML][HTML] Study on folate binding domain of dihydrofolate reductase in different plant species and human beings

A Samanta, AK Datta, S Datta - Bioinformation, 2014 - ncbi.nlm.nih.gov
Data base (NCBI and TIGR) searches are made to retrieve protein sequences of different
plant species namely Medicago truncatula, Pisum sativum, Ricinus communis, Arabidopsis …