The hitchhiker's guide to dynamic ion–solvent clustering: applications in differential ion mobility spectrometry

C Ieritano, WS Hopkins - Physical Chemistry Chemical Physics, 2022 - pubs.rsc.org
This article highlights the fundamentals of ion–solvent clustering processes that are
pertinent to understanding an ion's behaviour during differential mobility spectrometry (DMS) …

Argentination: A silver bullet for cannabinoid separation by differential mobility spectrometry

C Ieritano, P Thomas, WS Hopkins - Analytical Chemistry, 2023 - ACS Publications
As the legality of cannabis continues to evolve globally, there is a growing demand for
methods that can accurately quantitate cannabinoids found in commercial products …

Impact of ambient vapors present in an electrospray ionization source on gas-phase ion structures

Z Zheng, AB Attygalle - Journal of the American Society for Mass …, 2021 - ACS Publications
According to current consensus, structures of protomeric (or deprotomeric) tautomers of
gaseous ions generated by electrospray ionization depend primarily on the nature of the …

Protonation‐Induced Chirality Drives Separation by Differential Ion Mobility Spectrometry

C Ieritano, JC Yves Le Blanc, BB Schneider… - Angewandte …, 2022 - Wiley Online Library
Upon development of a workflow to analyze (±)‐Verapamil and its metabolites using
differential mobility spectrometry (DMS), we noticed that the ionogram of protonated …

Discrimination between protonation isomers of quinazoline by ion mobility and UV-photodissociation action spectroscopy

SJP Marlton, BI McKinnon, B Ucur… - The Journal of …, 2020 - ACS Publications
The influence of oriented electric fields on chemical reactivity and photochemistry is an area
of increasing interest. Within a molecule, different protonation sites offer the opportunity to …

Dependence of Collision-Induced Mass Spectra of Protonated Michler's Ketone on the Nature of LC-MS Mobile Phase

M Kumar, I Samarasinghe… - Journal of the American …, 2023 - ACS Publications
Michler's ketone (MK) is a dimethylamino ketone that undergoes facile protonation under
electrospray-ionization conditions to produce an ion of m/z 269. Initial LC-MS results …

Selecting and identifying gas-phase protonation isomers of nicotineH+ using combined laser, ion mobility and mass spectrometry techniques

SJP Marlton, BI McKinnon, B Ucur, AT Maccarone… - Faraday …, 2019 - pubs.rsc.org
The detection and assignment of protonation isomers, termed protomers, of gas-phase ions
remains a challenge in mass spectrometry. With the emergence of ion-mobility techniques …

Improved First-Principles Model of Differential Mobility Using Higher Order Two-Temperature Theory

A Haack, JR Bissonnette, C Ieritano… - Journal of the American …, 2022 - ACS Publications
Differential mobility spectrometry is a separation technique that may be applied to a variety
of analytes ranging from small molecule drugs to peptides and proteins. Although …

Solvent-Mediated Proton-Transfer Catalysis of the Gas-Phase Isomerization of Ciprofloxacin Protomers

B Ucur, AT Maccarone, SR Ellis… - Journal of the …, 2022 - ACS Publications
Understanding how neutral molecules become protonated during positive-ion electrospray
ionization (ESI) mass spectrometry is critically important to ensure analytes can be efficiently …

Studying the Key Intermediate of RNA Autohydrolysis by Cryogenic Gas‐Phase Infrared Spectroscopy

K Greis, C Kirschbaum, MI Taccone… - Angewandte Chemie …, 2022 - Wiley Online Library
Over the course of the COVID‐19 pandemic, mRNA‐based vaccines have gained
tremendous importance. The development and analysis of modified RNA molecules benefit …