The Jag2/Notch1 signaling axis promotes sebaceous gland differentiation and controls progenitor proliferation

SNF Abidi, S Chan, K Seidel, D Lafkas, L Vermeulen… - eLife, 2024 - elifesciences.org
The sebaceous gland (SG) is a vital appendage of the epidermis, and its normal
homeostasis and function is crucial for effective maintenance of the skin barrier. Notch …

NF-κB Mediated Thyroid Inflammation and Its Implications for the Risk of Follicular Thyroid Carcinoma: a systematic review

O Shafi, FNU Raveena, F Arshad, F Kanwal, OJ Khan… - medRxiv, 2024 - medrxiv.org
Objective: The objective of this study is to determine how NF-κB mediated inflammation
disrupts thyroid specific genes/TFs/signaling pathways and the resultant increase in the risk …

A developmental cell atlas of the human thyroid gland

H Massalha, MK Trinh, E Armingol, L Tuck, A Predeus… - bioRxiv, 2024 - biorxiv.org
The primary function of the thyroid gland is the synthesis and release of thyroid hormones,
which are essential for health from embryogenesis to adulthood. Thyroid disorders occur …

Notch Signaling Drives Pro-Regenerative and Migratory Traits in Glandular Stem/Progenitor Cells

D Cinat, R Maturi, JP Gunawan, AL Jellema-de Bruin… - bioRxiv, 2024 - biorxiv.org
Organoid models have advanced our understanding of adult stem/progenitor cell dynamics
and function. However, uncovering the regulatory mechanisms of scarce and often …