Solid phase screenings of one bead one compound (OBOC) libraries have been widely
used to find ligands with pharmacological and analytical uses, and to purify or detect …

The ability to rapidly and accurately evaluate bioactive compounds immobilized on porous
particles is crucial in the discovery of drugs, diagnostic reagents, ligands, and catalysts …

Screening solid-phase combinatorial libraries of bioactive compounds against fluorescently
labeled target biomolecules is an established technology in ligand and drug discovery …

From the initial steps of early drug discovery, the traditional techniques, like docking, QSAR,
or molecular dynamics, have been used for decades identifying targets, ranking molecule …

Peptide ligands are widely used in protein purification by affinity chromatography. Here, we
applied a fully automated two-stage library screening method that avoids false positive …

Combinatorial library screening coupled to mass spectrometry (MS) analysis is a practical
approach to identify useful peptides. Cyclic peptides can have high biological activity …

In this chapter, a protocol to design affinity chromatography matrices with short peptide
ligands immobilized for protein purification is described. The first step consists of the …

From the initial steps of early drug discovery, the traditional techniques, like docking, QSAR,
or molecular dynamics, have been used for decades identifying targets, ranking molecule …

The ability of a ligand to form a selective, high affinity interaction with a target molecule is a
fundamental mechanism for biological systems. Of the numerous applications in which …

The ability to rapidly and accurately evaluate bioactive compounds immobilized on porous
particles is crucial in the discovery of drugs, diagnostic reagents, ligands, and catalysts …