Microglia, the immunocompetent cells of the central nervous system (CNS), act as
neuropathology sensors and are neuroprotective under physiological conditions. Microglia …

Glaucoma is a group of diseases characterized by progressive optic nerve degeneration that
results in visual field loss and irreversible blindness. A crucial element in the …

Over 60 million people worldwide are diagnosed with glaucomatous optic neuropathy,
which is estimated to be responsible for 8.4 million cases of irreversible blindness globally …

Reactive oxygen species (ROS) are generated as by-products of cellular metabolism,
primarily in the mitochondria. Although ROS are essential participants in cell signaling and …

Mitochondrial dysfunction and excessive inflammatory responses are both sufficient to
induce pathology in age-dependent neurodegenerations. However, emerging evidence …

Purpose.: Elevated intraocular pressure (IOP) is an important risk factor for glaucoma.
Animal models often involve techniques for IOP elevation that are surgically invasive. Here …

Glaucoma as a neurodegenerative disease is a valid working hypothesis to understand
neural injury in the visual system. This paradigm may stimulate the discovery of innovative …

An early hallmark of neuronal degeneration is distal transport loss and axon pathology.
Glaucoma involves the degeneration of retinal ganglion cell (RGC) neurons and their axons …

Alzheimer's disease (AD) is the most common cause of dementia in the elderly. In the
pathogenesis of AD a pivotal role is played by two neurotoxic proteins that aggregate and …

Background: Open Angle Glaucoma (POAG) is the leading causes of irreversible blindness
worldwide. Elevated intraocular pressure is considered an important risk factor for …