APOBEC3G and APOBEC3F act in concert to extinguish HIV-1 replication
JF Krisko, N Begum, CE Baker, JL Foster… - Journal of …, 2016 - Am Soc Microbiol
The multifunctional HIV-1 accessory protein Vif counters the antiviral activities of
APOBEC3G (A3G) and APOBEC3F (A3F), and some Vifs counter stable alleles of …
APOBEC3G (A3G) and APOBEC3F (A3F), and some Vifs counter stable alleles of …
HIV-1 Vif's capacity to manipulate the cell cycle is species specific
EL Evans III, JT Becker, SL Fricke, K Patel… - Journal of …, 2018 - Am Soc Microbiol
Cells derived from mice and other rodents exhibit profound blocks to HIV-1 virion production,
reflecting species-specific incompatibilities between viral Tat and Rev proteins and essential …
reflecting species-specific incompatibilities between viral Tat and Rev proteins and essential …
APOBEC3B potently restricts HIV-2 but not HIV-1 in a Vif-dependent manner
S Bandarra, E Miyagi, AC Ribeiro, J Gonçalves… - Journal of …, 2021 - Am Soc Microbiol
Vif is a lentiviral accessory protein that counteracts the antiviral activity of cellular APOBEC3
(A3) cytidine deaminases in infected cells. The exact contribution of each member of the A3 …
(A3) cytidine deaminases in infected cells. The exact contribution of each member of the A3 …
Impact of suboptimal APOBEC3G neutralization on the emergence of HIV drug resistance in humanized mice
MM Hernandez, A Fahrny, A Jayaprakash… - Journal of …, 2020 - Am Soc Microbiol
ABSTRACT HIV diversification facilitates immune escape and complicates antiretroviral
therapy. In this study, we take advantage of a humanized-mouse model to probe the …
therapy. In this study, we take advantage of a humanized-mouse model to probe the …
Functional and structural insights into a Vif/PPP2R5 complex elucidated using patient HIV-1 isolates and computational modeling
Human immunodeficiency virus type 1 (HIV-1) Vif recruits a cellular ubiquitin ligase complex
to degrade antiviral APOBEC3 enzymes (APOBEC3C-H) and PP2A phosphatase regulators …
to degrade antiviral APOBEC3 enzymes (APOBEC3C-H) and PP2A phosphatase regulators …
Flexibility in nucleic acid binding is central to APOBEC3H antiviral activity
JA Bohn, J DaSilva, S Kharytonchyk… - Journal of …, 2019 - Am Soc Microbiol
ABSTRACT APOBEC3 proteins APOBEC3F (A3F), APOBEC3G (A3G), and APOBEC3H
(A3H) are host restriction factors that inhibit HIV-1 through DNA cytidine deaminase …
(A3H) are host restriction factors that inhibit HIV-1 through DNA cytidine deaminase …
Conserved interaction of lentiviral Vif molecules with HIV-1 Gag and differential effects of species-specific Vif on virus production
W Zheng, L Ling, Z Li, H Wang, Y Rui, W Gao… - Journal of …, 2017 - Am Soc Microbiol
The virion infectivity factor (Vif) open reading frame is conserved among most lentiviruses.
Vif molecules contribute to viral replication by inactivating host antiviral factors, the …
Vif molecules contribute to viral replication by inactivating host antiviral factors, the …