Heart failure is the leading cause of death worldwide. The inability of the adult mammalian
heart to regenerate following injury results in the development of systolic heart failure. Thus …

Aims Metabolic switching during heart development contributes to postnatal cardiomyocyte
(CM) cell cycle exit and loss of regenerative capacity in the mammalian heart. Metabolic …

Cardiovascular diseases are the leading cause of death worldwide, among which ischemic
heart disease is the most representative. Myocardial infarction results from occlusion of a …

Adult (3 month) mice with cardiac-specific overexpression of adenylyl cyclase (AC) type VIII
(TG AC8) adapt to an increased cAMP-induced cardiac workload (~ 30% increases in heart …

Aims The coordinated gene and metabolic programs that facilitate cardiomyocyte entry and
progression in the cell cycle are poorly understood. The purpose of this study was to identify …

As a biological pump, the heart needs to consume a substantial amount of energy to
maintain sustained beating. Myocardial energy metabolism was recently reported to be …

Introduction: Removal of poorly perfused capillaries by pruning contributes to remodeling
the microvasculature to optimize oxygen and nutrient delivery. Blood flow drives this process …

Cardiovascular disease is a leading cause of death worldwide. Due to the limited
proliferative and regenerative capacity of adult cardiomyocytes, the lost myocardium is not …

It is well established that humans and other mammals are minimally regenerative compared
with organisms such as zebrafish, salamander or amphibians. In recent years, however, the …

Heart disease continues to be the leading cause of mortality worldwide, primarily attributed
to the restricted regenerative potential of the adult human heart following injury. In contrast to …