Ocular biomarkers for early detection of Alzheimer's disease

S Frost, RN Martins… - Journal of Alzheimer's …, 2010 - content.iospress.com
Alzheimer's disease (AD) is the most common form of dementia and is clinically
characterized by a progressive decline in memory, learning, and executive functions, and …

Cholinergic deficiency in Alzheimer's and Parkinson's disease: evaluation with pupillometry

DF Fotiou, V Stergiou, D Tsiptsios, C Lithari… - International Journal of …, 2009 - Elsevier
The aim of the study was to evaluate the cholinergic deficiency in Alzheimer's (AD) and
Parkinson's disease (PD). For this purpose, pupil size changes and mobility were assessed …

Changes in pupil reaction to light in Alzheimer's disease patients: a preliminary report

F Fotiou, KN Fountoulakis, M Tsolaki, A Goulas… - International journal of …, 2000 - Elsevier
The aim of this preliminary study was to compare the pupil reaction to light in Alzheimer's
disease (AD) patients before and after treatment and in normal controls. Ten AD patients …

Tropicamide effects on pupil size and pupillary light reflexes in Alzheimer's and Parkinson's disease

E Granholm, S Morris, D Galasko, C Shults… - International Journal of …, 2003 - Elsevier
Diagnostic tests for Alzheimer's disease (AD) involving tropicamide blockade of cholinergic
oculomotor functions were examined in AD patients (n= 15), Parkinson's disease (PD) …

Pupil reaction to light in Alzheimer's disease: evaluation of pupil size changes and mobility

DF Fotiou, CG Brozou, AB Haidich, D Tsiptsios… - Aging clinical and …, 2007 - Springer
Aims: The aim of the study is to assess pupil size changes and mobility evaluation as a
diagnostic marker in patients with probable Alzheimer's disease (AD). Material and methods …

Evaluation of the cholinergic hypothesis in Alzheimer's disease with neuropsychological methods

D Fotiou, A Kaltsatou, D Tsiptsios, M Nakou - Aging clinical and …, 2015 - Springer
Aim This study aimed at evaluating the cholinergic hypothesis in Alzheimer's disease (AD)
patients utilizing the pupillometry method, cognitive tests and Hamilton Depression Rating …

Repetitive pupil light reflex: potential marker in Alzheimer's disease?

DM Bittner, I Wieseler, H Wilhelm… - Journal of …, 2014 - content.iospress.com
It was investigated whether alterations of the pupil's light reflex might reflect Alzheimer's
disease (AD) pathology. Changes in the pupil's system might be expected due to AD …

Selective cell loss in Edinger-Westphal in asymptomatic elders and Alzheimer's patients

LFM Scinto, M Frosch, CK Wu, KR Daffner, N Gedi… - Neurobiology of …, 2001 - Elsevier
Exaggerated pupillary response to a low concentration of cholinergic antagonists has been
suggested as an early marker for Alzheimer's Disease (AD). To examine the anatomic basis …

Focal pathology in the Edinger-Westphal nucleus explains pupillary hypersensitivity in Alzheimer's disease

LFM Scinto, CK Wu, KM Firla, KR Daffner, D Saroff… - Acta …, 1999 - Springer
Patients who suffer from Alzheimer's disease (AD) and a sub-population of community-
dwelling elders show an exaggerated pupillary reaction to dilute tropicamide, a cholinergic …

Pupil response biomarkers distinguish amyloid precursor protein mutation carriers from non-carriers

SM Frost, Y Kanagasingam… - Current Alzheimer …, 2013 - ingentaconnect.com
Context: Alzheimer's disease (AD) is usually only diagnosed many years after pathology
begins. Earlier detection would allow emerging interventions to have a greater chance to …