Since the first use of Chinese hamster ovary (CHO) cells for recombinant protein expression,
production processes have steadily improved through numerous advances. In this review …

The manufacturing of recombinant protein is traditionally undertaken in mammalian cell
culture. Today, speed, cost and safety are the primary considerations for process …

The manufacturing of recombinant protein is traditionally divided in two main steps:
upstream (cell culture and synthesis of the target protein) and downstream (purification and …

There is a growing interest in realizing the benefits of continuous processing in biologics
manufacturing, which is reflected by the significant number of industrial and academic …

A steady increase of product titers and the corresponding change in impurity composition
represent a challenge for development and optimization of antibody production processes …

Apoptosis is a form of programmed and controlled cell death that accounts for the majority of
cellular death in bioprocesses. Cell death affects culture longevity and product quality; it is …

Cultured meat, as a cellular agriculture product, utilizes tissue engineering techniques and
consequently faces not only cell culture challenges but also scale-up limitations. To ensure …

More than two decades after the highly-cited review on microfiltration of suspensions and
macromolecular solutions, it is time to revisit and update the fundamentals and applications …

Process intensification strives for more efficient conversion of raw materials into products
while minimizing resource usage. In the biopharma industry, typical intensification gains …

In this study, we demonstrated the first, to our knowledge, integrated continuous bioprocess
(ICB) designed for the production of acid‐sensitive monoclonal antibodies, prone to …