Structure-activity relationship (SAR) study and design strategies of nitrogen-containing heterocyclic moieties for their anticancer activities
The present review article offers a detailed account of the design strategies employed for the
synthesis of nitrogen-containing anticancer agents. The results of different studies describe …
synthesis of nitrogen-containing anticancer agents. The results of different studies describe …
Hybrid molecules: The privileged scaffolds for various pharmaceuticals
S Mishra, P Singh - European journal of medicinal chemistry, 2016 - Elsevier
The practice of polypharmacology is not a new concept but the approaches which are being
adopted for administering the two or more drugs together are varied from time to time …
adopted for administering the two or more drugs together are varied from time to time …
Design and synthesis of thiazolidine-2, 4-diones hybrids with 1, 2-dihydroquinolones and 2-oxindoles as potential VEGFR-2 inhibitors: In-vitro anticancer evaluation …
Abstract A thiazolidine-2, 4-dione nucleus was molecularly hybridised with the effective
antitumor moieties; 2-oxo-1, 2-dihydroquinoline and 2-oxoindoline to obtain new hybrids …
antitumor moieties; 2-oxo-1, 2-dihydroquinoline and 2-oxoindoline to obtain new hybrids …
A review on anticancer potential of bioactive heterocycle quinoline
The advent of Camptothecin added a new dimension in the field anticancer drug
development containing quinoline motif. Quinoline scaffold plays an important role in …
development containing quinoline motif. Quinoline scaffold plays an important role in …
Thiazole: A review on chemistry, synthesis and therapeutic importance of its derivatives
M T. Chhabria, S Patel, P Modi… - Current topics in …, 2016 - benthamdirect.com
Thiazole, a unique heterocycle containing sulphur and nitrogen atoms, occupies an
important place in medicinal chemistry. It is an essential core scaffold present in many …
important place in medicinal chemistry. It is an essential core scaffold present in many …
Quinolone hybrids and their anti-cancer activities: An overview
F Gao, X Zhang, T Wang, J Xiao - European journal of medicinal chemistry, 2019 - Elsevier
The global pandemic of drug-sensitive cancers and the increasing threat from drug-resistant
cancers make an urgent need to develop more effective anti-cancer candidates. Quinolone …
cancers make an urgent need to develop more effective anti-cancer candidates. Quinolone …
Recent advances in the synthetic and medicinal perspective of quinolones: A review
In the modern scenario, the quinolone scaffold has emerged as a very potent motif
considering its clinical significance. Quinolones possess wide range of pharmacological …
considering its clinical significance. Quinolones possess wide range of pharmacological …
Thiazolidine-2, 4-diones as multi-targeted scaffold in medicinal chemistry: Potential anticancer agents
A variety of substituents on the thiazolidine-2, 4-dione (TZD) nucleus have provided a wide
spectrum of biological activities by the using of different mechanism on various target sites …
spectrum of biological activities by the using of different mechanism on various target sites …
A comprehensive review of N-heterocycles as cytotoxic agents
D Kumar, S Kumar Jain - Current Medicinal Chemistry, 2016 - ingentaconnect.com
Scientific community is striving to understand the role of heterocycles and fused
heterocycles in drug discovery programme due to its impact on multi-drug resistance (MDR) …
heterocycles in drug discovery programme due to its impact on multi-drug resistance (MDR) …
Design and synthesis of novel 2-phenyl-5-(1, 3-diphenyl-1H-pyrazol-4-yl)-1, 3, 4-oxadiazoles as selective COX-2 inhibitors with potent anti-inflammatory activity
A novel series of 2-phenyl-5-(1, 3-diphenyl-1H-pyrazol-4-yl)-1, 3, 4-oxadiazoles were
designed and synthesized for selective COX-2 inhibition with potent anti-inflammatory …
designed and synthesized for selective COX-2 inhibition with potent anti-inflammatory …