The ubiquitin proteasome system (UPS) is the main system for controlled protein
degradation and a key regulator of fundamental cellular processes. The dependency of …

Ubiquitylation and deubiquitylation are reversible protein post-translational modification
(PTM) processes involving the regulation of protein degradation under physiological …

Loss-of-function mutations in PARK2, the gene encoding the E3 ubiquitin ligase Parkin, are
the most frequent cause of recessive Parkinson's disease (PD). Parkin translocates from the …

Protein ubiquitination is an important mechanism for regulating the activity and levels of
proteins under physiological conditions. Loss of regulation by protein ubiquitination leads to …

The nuclear factor‐κB (NF‐κB) pathway is a critical regulator of innate and adaptive
immunity. Noncanonical K63‐linked polyubiquitination plays a key regulatory role in NF‐κB …

p21WAF1/CIP1 is a broad-acting cyclin-dependent kinase inhibitor. Its stability is essential
for proper cell-cycle progression and cell fate decision. Ubiquitylation by the multiple E3 …

The ubiquitin–proteasome system (UPS) has emerged as a therapeutic focus and target for
the treatment of cancer. The most clinically successful UPS-active agents (bortezomib and …

TNFα is a key mediator of immune, chemotherapy and radiotherapy-induced cytotoxicity, but
several cancers, including head and neck squamous cell carcinomas (HNSCC), display …

The aberrant expression of ubiquitin-specific protease 11 (USP11) is believed to be related
to tumor progression. However, few studies have reported the biological function and clinical …

The worldwide SARS-CoV-2 outbreak poses a serious challenge to human societies and
economies. SARS-CoV-2 proteins orchestrate complex pathogenic mechanisms that …