The functional roles of PML nuclear bodies in genome maintenance
HR Chang, A Munkhjargal, MJ Kim, SY Park… - Mutation Research …, 2018 - Elsevier
In the nucleus, there are several membraneless structures called nuclear bodies. Among
them, promyelocytic leukemia nuclear bodies (PML-NBs) are involved in multiple genome …
them, promyelocytic leukemia nuclear bodies (PML-NBs) are involved in multiple genome …
Functional interrogation of DNA damage response variants with base editing screens
Mutations in DNA damage response (DDR) genes endanger genome integrity and
predispose to cancer and genetic disorders. Here, using CRISPR-dependent cytosine base …
predispose to cancer and genetic disorders. Here, using CRISPR-dependent cytosine base …
Epigenetic modification and a role for the E3 ligase RNF40 in cancer development and metastasis
Abstract RNF40 (OMIM: 607700) is a really interesting new gene (RING) finger E3 ubiquitin
ligase containing multiple coiled-coil domains and a C-terminal RING finger motif, which …
ligase containing multiple coiled-coil domains and a C-terminal RING finger motif, which …
TRAIP resolves DNA replication-transcription conflicts during the S-phase of unperturbed cells
S Scaramuzza, RM Jones, MM Sadurni… - Nature …, 2023 - nature.com
Cell division is the basis for the propagation of life and requires accurate duplication of all
genetic information. DNA damage created during replication (replication stress) is a major …
genetic information. DNA damage created during replication (replication stress) is a major …
RNF168-mediated localization of BARD1 recruits the BRCA1-PALB2 complex to DNA damage
DNA damage prompts a diverse range of alterations to the chromatin landscape. The
RNF168 E3 ubiquitin ligase catalyzes the mono-ubiquitination of histone H2A at lysine (K) …
RNF168 E3 ubiquitin ligase catalyzes the mono-ubiquitination of histone H2A at lysine (K) …
Mitotic CDK promotes replisome disassembly, fork breakage, and complex DNA rearrangements
DNA replication errors generate complex chromosomal rearrangements and thereby
contribute to tumorigenesis and other human diseases. One mechanism that triggers these …
contribute to tumorigenesis and other human diseases. One mechanism that triggers these …
DOT1L-mediated RAP80 methylation promotes BRCA1 recruitment to elicit DNA repair
H Tang, YF Lu, R Zeng, C Liu, Y Shu, Y Wu… - Proceedings of the …, 2024 - pnas.org
Breast Cancer Type 1 Susceptibility Protein (BRCA1) is a tumor-suppressor protein that
regulates various cellular pathways, including those that are essential for preserving …
regulates various cellular pathways, including those that are essential for preserving …
TRAIP drives replisome disassembly and mitotic DNA repair synthesis at sites of incomplete DNA replication
R Sonneville, R Bhowmick, S Hoffmann, N Mailand… - Elife, 2019 - elifesciences.org
The faithful segregation of eukaryotic chromosomes in mitosis requires that the genome be
duplicated completely prior to anaphase. However, cells with large genomes sometimes fail …
duplicated completely prior to anaphase. However, cells with large genomes sometimes fail …
PRMT5 promotes DNA repair through methylation of 53BP1 and is regulated by Src-mediated phosphorylation
PRMT5 participates in various cellular processes, including transcription regulation, signal
transduction, mRNA splicing, and DNA repair; however, its mechanism of regulation is …
transduction, mRNA splicing, and DNA repair; however, its mechanism of regulation is …
Meta-analysis of DNA double-strand break response kinetics
JA Kochan, ECB Desclos, R Bosch… - Nucleic acids …, 2017 - academic.oup.com
Most proteins involved in the DNA double-strand break response (DSBR) accumulate at the
damage sites, where they perform functions related to damage signaling, chromatin …
damage sites, where they perform functions related to damage signaling, chromatin …