Neural stem cells: origin, heterogeneity and regulation in the adult mammalian brain

K Obernier, A Alvarez-Buylla - Development, 2019 - journals.biologists.com
In the adult rodent brain, neural stem cells (NSCs) persist in the ventricular-subventricular
zone (V-SVZ) and the subgranular zone (SGZ), which are specialized niches in which young …

The adult ventricular–subventricular zone (V-SVZ) and olfactory bulb (OB) neurogenesis

DA Lim, A Alvarez-Buylla - Cold Spring Harbor …, 2016 - cshperspectives.cshlp.org
A large population of neural stem/precursor cells (NSCs) persists in the ventricular–
subventricular zone (V-SVZ) located in the walls of the lateral brain ventricles. V-SVZ NSCs …

Time is spine: a review of translational advances in spinal cord injury: JNSPG 75th Anniversary Invited Review Article

JH Badhiwala, CS Ahuja, MG Fehlings - Journal of Neurosurgery: Spine, 2018 - thejns.org
Acute traumatic spinal cord injury (SCI) is a devastating event with far-reaching physical,
emotional, and economic consequences for patients, families, and society at large. Timely …

Embryonic origin of postnatal neural stem cells

LC Fuentealba, SB Rompani, JI Parraguez, K Obernier… - Cell, 2015 - cell.com
Adult neural stem/progenitor (B1) cells within the walls of the lateral ventricles generate
different types of neurons for the olfactory bulb (OB). The location of B1 cells determines the …

Prospective identification and purification of quiescent adult neural stem cells from their in vivo niche

P Codega, V Silva-Vargas, A Paul… - Neuron, 2014 - cell.com
Adult neurogenic niches harbor quiescent neural stem cells; however, their in vivo identity
has been elusive. Here, we prospectively isolate GFAP+ CD133+(quiescent neural stem …

Adult neurogenesis in the mammalian brain: significant answers and significant questions

G Ming, H Song - Neuron, 2011 - cell.com
Adult neurogenesis, a process of generating functional neurons from adult neural
precursors, occurs throughout life in restricted brain regions in mammals. The past decade …

Single-cell analysis of the ventricular-subventricular zone reveals signatures of dorsal and ventral adult neurogenesis

A Cebrian-Silla, MA Nascimento, SA Redmond… - Elife, 2021 - elifesciences.org
The ventricular-subventricular zone (V-SVZ), on the walls of the lateral ventricles, harbors
the largest neurogenic niche in the adult mouse brain. Previous work has shown that neural …

Cancer stem cells: an evolving concept

LV Nguyen, R Vanner, P Dirks, CJ Eaves - Nature Reviews Cancer, 2012 - nature.com
The cancer stem cell (CSC) concept derives from the fact that cancers are dysregulated
tissue clones whose continued propagation is vested in a biologically distinct subset of cells …

Role of EGFR in the Nervous System

R Romano, C Bucci - Cells, 2020 - mdpi.com
Epidermal growth factor receptor (EGFR) is the first discovered member of the receptor
tyrosine kinase superfamily and plays a fundamental role during embryogenesis and in …

Gut bacteria signaling to mitochondria in intestinal inflammation and cancer

DN Jackson, AL Theiss - Gut microbes, 2020 - Taylor & Francis
The gastrointestinal microbiome plays a pivotal role in physiological homeostasis of the
intestine as well as in the pathophysiology of diseases including inflammatory bowel …