Coordinating radiometals of copper, gallium, indium, yttrium, and zirconium for PET and SPECT imaging of disease

TJ Wadas, EH Wong, GR Weisman… - Chemical …, 2010 - ACS Publications
Molecular imaging is the visualization, characterization, and measurement of biological
processes at the molecular and cellular levels in humans and other living systems …

Copper-64 radiopharmaceuticals for PET imaging of cancer: advances in preclinical and clinical research

CJ Anderson, R Ferdani - Cancer Biotherapy and …, 2009 - liebertpub.com
Summation Copper-64 (T1/2= 12.7 hours; β+, 0.653 MeV [17.8%]; β−, 0.579 MeV [38.4%])
has decay characteristics that allow for positron emission tomography (PET) imaging and …

Radiopharmaceutical chemistry for positron emission tomography

Z Li, PS Conti - Advanced drug delivery reviews, 2010 - Elsevier
Molecular imaging is an emerging technology that allows the visualization of interactions
between molecular probes and biological targets. Molecules that either direct or are subject …

Development of copper based drugs, radiopharmaceuticals and medical materials

P Szymański, T Frączek, M Markowicz… - Biometals, 2012 - Springer
Copper is one of the most interesting elements for various biomedical applications. Copper
compounds show vast array of biological actions, including anti-inflammatory, anti …

Radioimmunoimaging with longer-lived positron-emitting radionuclides: potentials and challenges

TK Nayak, MW Brechbiel - Bioconjugate chemistry, 2009 - ACS Publications
Radioimmunoimaging and therapy has been an area of interest for several decades. Steady
progress has been made toward clinical translation of radiolabeled monoclonal antibodies …

Metallic radionuclides in the development of diagnostic and therapeutic radiopharmaceuticals

S Bhattacharyya, M Dixit - Dalton transactions, 2011 - pubs.rsc.org
Metallic radionuclides are the mainstay of both diagnostic and therapeutic
radiopharmaceuticals. Therapeutic nuclear medicine is less advanced but has tremendous …

64Cu-AMD3100—a novel imaging agent for targeting chemokine receptor CXCR4

O Jacobson, ID Weiss, L Szajek, JM Farber… - Bioorganic & medicinal …, 2009 - Elsevier
CXCR4 is a chemokine receptor which has been shown to be exploited by various tumors
for increased survival, invasion, and homing to target organs. We developed a one step …

[HTML][HTML] First-in-human uPAR PET: imaging of cancer aggressiveness

M Persson, D Skovgaard, M Brandt-Larsen… - Theranostics, 2015 - ncbi.nlm.nih.gov
A first-in-human clinical trial with Positron Emission Tomography (PET) imaging of the
urokinase-type plasminogen activator receptor (uPAR) in patients with breast, prostate and …

Engineering of affibody molecules for therapy and diagnostics

J Feldwisch, V Tolmachev - Therapeutic Proteins: Methods and Protocols, 2012 - Springer
Affibody molecules are small and robust non-immunoglobulin affinity ligands capable of
binding to a wide range of protein targets. They are selected from combinatorial libraries …

Synthesis and radiolabeling of chelator–RNA aptamer bioconjugates with copper-64 for targeted molecular imaging

WM Rockey, L Huang, KC Kloepping… - Bioorganic & medicinal …, 2011 - Elsevier
Ribonucleic acid (RNA) aptamers with high affinity and specificity for cancer-specific cell-
surface antigens are promising reagents for targeted molecular imaging of cancer using …