DGKs (diacylglycerol kinases) are members of a unique and conserved family of
intracellular lipid kinases that phosphorylate DAG (diacylglycerol), catalysing its conversion …

Diacylglycerol (DAG) kinase (DGK) modulates the balance between the two signaling lipids,
DAG and phosphatidic acid (PA), by phosphorylating DAG to yield PA. To date, ten …

Purpose: Immunotherapy using vaccines or adoptively transferred tumor-infiltrating
lymphocytes (TIL) is limited by T-cell functional inactivation within the solid tumor …

In lymphocytes, integration of Ca 2+ and other signaling pathways results in productive
activation, while unopposed Ca 2+ signaling leads to tolerance or anergy. We show that the …

T cell anergy has been correlated with defective signaling by the GTPase Ras, but causal
and mechanistic data linking defective Ras activity with T cell anergy are lacking. Here we …

Diacylglycerol (DAG) is an important lipid that is both an intermediate in lipid biosynthetic
pathways and can act as a signaling lipid. The majority of signaling DAG is generated by …

The reorientation of the T cell microtubule-organizing center (MTOC) toward the antigen-
presenting cell enables the directional secretion of cytokines and lytic factors. By single-cell …

The precise timing of signals downstream of the T cell receptor (TCR) is poorly understood.
To address this problem, we prepared major histocompatibility complexes containing an …

Diacylglycerol kinases (DGKs) attenuate diacylglycerol (DAG) signaling by converting DAG
to phosphatidic acid, thereby suppressing pathways downstream of T cell receptor signaling …

Cytidine diphosphate diacylglycerol (CDP-DAG) is a key intermediate in the synthesis of
phosphatidylinositol (PI) and cardiolipin (CL). Both PI and CL have highly specialized roles …