Biophysics in tumor growth and progression: from single mechano-sensitive molecules to mechanomedicine

Y Xin, K Li, M Huang, C Liang, D Siemann, L Wu, Y Tan… - Oncogene, 2023 - nature.com
Evidence from physical sciences in oncology increasingly suggests that the interplay
between the biophysical tumor microenvironment and genetic regulation has significant …

DNA structure and function

A Travers, G Muskhelishvili - The FEBS journal, 2015 - Wiley Online Library
The proposal of a double‐helical structure for DNA over 60 years ago provided an eminently
satisfying explanation for the heritability of genetic information. But why is DNA, and not …

All eukaryotic SMC proteins induce a twist of− 0.6 at each DNA loop extrusion step

R Janissen, R Barth, IF Davidson, JM Peters… - Science …, 2024 - science.org
Eukaryotes carry three types of structural maintenance of chromosome (SMC) protein
complexes, condensin, cohesin, and SMC5/6, which are ATP-dependent motor proteins that …

Non-contact long-range magnetic stimulation of mechanosensitive ion channels in freely moving animals

J Lee, W Shin, Y Lim, J Kim, WR Kim, H Kim, JH Lee… - Nature materials, 2021 - nature.com
Among physical stimulation modalities, magnetism has clear advantages, such as deep
penetration and untethered interventions in biological subjects. However, some of the …

Spatially selective manipulation of cells with single-beam acoustical tweezers

M Baudoin, JL Thomas, RA Sahely… - Nature …, 2020 - nature.com
Acoustical tweezers open major prospects in microbiology for cells and microorganisms
contactless manipulation, organization and mechanical properties testing since they are …

Single-molecule force spectroscopy: optical tweezers, magnetic tweezers and atomic force microscopy

KC Neuman, A Nagy - Nature methods, 2008 - nature.com
Single-molecule force spectroscopy has emerged as a powerful tool to investigate the forces
and motions associated with biological molecules and enzymatic activity. The most common …

Optical trapping

KC Neuman, SM Block - Review of scientific instruments, 2004 - pubs.aip.org
Since their invention just over 20 years ago, optical traps have emerged as a powerful tool
with broad-reaching applications in biology and physics. Capabilities have evolved from …

Microscopic artificial swimmers

R Dreyfus, J Baudry, ML Roper, M Fermigier, HA Stone… - Nature, 2005 - nature.com
Microorganisms such as bacteria and many eukaryotic cells propel themselves with hair-like
structures known as flagella, which can exhibit a variety of structures and movement …

Ten years of tension: single-molecule DNA mechanics

C Bustamante, Z Bryant, SB Smith - Nature, 2003 - nature.com
The basic features of DNA were elucidated during the half-century following the discovery of
the double helix. But it is only during the past decade that researchers have been able to …

Cell and molecular mechanics of biological materials

G Bao, S Suresh - Nature materials, 2003 - nature.com
Living cells can sense mechanical forces and convert them into biological responses.
Similarly, biological and biochemical signals are known to influence the abilities of cells to …