Basal cell carcinoma (BCC) is the most common human cancer worldwide, and is a subtype
of nonmelanoma skin cancer, characterized by a constantly increasing incidence due to an …

During mammalian embryonic development, primary cilia transduce and regulate several
signaling pathways. Among the various pathways, Sonic hedgehog (SHH) is one of the most …

Triple-negative breast cancer (TNBC) is the most complex, aggressive and fatal subtype of
breast cancer. Owing to the lack of targeted therapy and heterogenic nature of TNBC …

Hedgehog (Hh) signaling is a highly conserved pathway that plays a vital role during
embryonic development. Recently, uncontrolled activation of this pathway has been …

Gli proteins are transcriptional effectors of the Hedgehog signaling pathway. They play key
roles in the development of many organs and tissues, and are deregulated in birth defects …

The Hedgehog (Hh) pathway is a signaling cascade that plays a crucial role in many
fundamental processes, including embryonic development and tissue homeostasis …

The current view is that breast cancer is a stem cell disease characterized by the existence
of cancer cells with stem-like features and tumor-initiating potential. These cells are made …

Breast cancer is a heterogeneous disease that is characterized by a high grade of cell
plasticity arising from the contribution of a diverse range of factors. When combined, these …

The hedgehog (Hh) pathway plays a key role in embryonic development and stem cell
programs. Deregulation of the Hh pathway is a key driver of basal cell carcinoma, and …

The Wnt, Hedgehog, and Notch pathways are inherent signaling pathways in normal
embryogenesis, development, and hemostasis. However, dysfunctions of these pathways …