The search for new lead compounds of simple structure, displaying highest quality anti-
tumor potency with new mechanisms of action and least adverse effects is the major …

Hearing loss is widespread and persistent because mature mammalian auditory hair cells
(HCs) are nonregenerative. In mice, the ability to regenerate HCs from surrounding …

Introduction More than 5% of the world's population have a disabling hearing loss which can
be managed by hearing aids or implanted electrical devices. However, outcomes are highly …

Disordered proteins are highly prevalent in biological systems, they control myriad signaling
and regulatory processes and their levels and/or cellular localization are often altered in …

To assess the potential of intrinsically disordered proteins (IDPs) as drug design targets, we
have analyzed the ligand‐binding cavities of two datasets of IDPs (containing 37 and 16 …

The sensory cells of the inner ear, called hair cells, do not regenerate spontaneously and
therefore, hair cell loss and subsequent hearing loss are permanent in humans. Conversely …

Noise-induced hearing loss (NIHL) affects a large number of military personnel and civilians.
Regenerating inner-ear cochlear hair cells (HCs) is a promising strategy to restore hearing …

The splicing of pre-mRNA is a critical process in normal cells and is deregulated in cancer.
Compounds that modulate this process have recently been shown to target a specific …

Epstein‐Barr virus (EBV) is a well‐established tumor virus that has been implicated in a
wide range of immunodeficiency‐associated lymphoproliferative disorders (LPDs). Although …

Splicing is an important eukaryotic mechanism for expanding the transcriptome and
proteome, influencing a number of biological processes. Understanding its regulation and …