Genetic instability, which includes both numerical and structural chromosomal
abnormalities, is a hallmark of cancer. Whereas the structural chromosome rearrangements …

The classical genetic approach for exploring biological pathways typically begins by
identifying mutations that cause a phenotype of interest. Overexpression or misexpression of …

Careful visual examination of biological samples is quite powerful, but many visual analysis
tasks done in the laboratory are repetitive, tedious, and subjective. Here we describe the use …

Many disease states result from gene overexpression, often in a specific genetic context. To
explore gene overexpression phenotypes systematically, we assembled an array of 5280 …

Cohesin establishes sister-chromatid cohesion from S phase until mitosis or meiosis. To
allow chromosome segregation, cohesion has to be dissolved. In vertebrate cells, this …

The development and application of genetic tools and resources has enabled a partial
genetic-interaction network for the yeast Saccharomyces cerevisiae to be compiled. Analysis …

The execution of complex biological processes requires the precise interaction and
regulation of thousands of molecules. Systematic approaches to study large numbers of …

The target of rapamycin complex 1 (TORC1) is a central regulator of eukaryotic cell growth
that is activated by a variety of hormones (eg, insulin) and nutrients (eg, amino acids) and is …

Chromatin-modifying factors have essential roles in DNA processing pathways that dictate
cellular functions. The ability of chromatin modifiers, including the INO80 and SWR1 …

The mitotic spindle is the macromolecular machine that segregates chromosomes to two
daughter cells during mitosis. The major structural elements of the spindle are microtubule …