Novel therapeutic strategies: Targeting epithelial–mesenchymal transition in colorectal cancer

N Zhang, AS Ng, S Cai, Q Li, L Yang, D Kerr - The lancet oncology, 2021 - thelancet.com
Epithelial–mesenchymal transition (EMT) is a process during which cells lose their epithelial
characteristics, for instance apical–basal cell polarity and cell–cell contact, and gain …

TGF-β Signaling

K Tzavlaki, A Moustakas - Biomolecules, 2020 - mdpi.com
Transforming growth factor-β (TGF-β) represents an evolutionarily conserved family of
secreted polypeptide factors that regulate many aspects of physiological embryogenesis …

The role of TGF-beta3 in cartilage development and osteoarthritis

X Du, L Cai, J Xie, X Zhou - Bone research, 2023 - nature.com
Articular cartilage serves as a low-friction, load-bearing tissue without the support with blood
vessels, lymphatics and nerves, making its repair a big challenge. Transforming growth …

Pathobiology of the klotho antiaging protein and therapeutic considerations

GJ Prud'homme, M Kurt, Q Wang - Frontiers in Aging, 2022 - frontiersin.org
The α-Klotho protein (henceforth denoted Klotho) has antiaging properties, as first observed
in mice homozygous for a hypomorphic Klotho gene (kl/kl). These mice have a shortened …

TGF-β signaling from receptors to Smads

A Hata, YG Chen - Cold Spring Harbor perspectives in …, 2016 - cshperspectives.cshlp.org
Transforming growth factor β (TGF-β) and related growth factors are secreted pleiotropic
factors that play critical roles in embryogenesis and adult tissue homeostasis by regulating …

Signaling receptors for TGF-β family members

CH Heldin, A Moustakas - Cold Spring Harbor …, 2016 - cshperspectives.cshlp.org
Transforming growth factor β (TGF-β) family members signal via heterotetrameric complexes
of type I and type II dual specificity kinase receptors. The activation and stability of the …

Clinical development of galunisertib (LY2157299 monohydrate), a small molecule inhibitor of transforming growth factor-beta signaling pathway

S Herbertz, JS Sawyer, AJ Stauber… - Drug design …, 2015 - Taylor & Francis
Transforming growth factor-beta (TGF-β) signaling regulates a wide range of biological
processes. TGF-β plays an important role in tumorigenesis and contributes to the hallmarks …

Transforming growth factor Beta family: insight into the role of growth factors in regulation of fracture healing biology and potential clinical applications

ŁA Poniatowski, P Wojdasiewicz, R Gasik… - Mediators of …, 2015 - Wiley Online Library
The transforming growth factor beta (TGF‐β) family forms a group of three isoforms, TGF‐β1,
TGF‐β2, and TGF‐β3, with their structure formed by interrelated dimeric polypeptide chains …

Fluorescent labeling and modification of proteins

CP Toseland - Journal of chemical biology, 2013 - Springer
This review provides an outline for fluorescent labeling of proteins. Fluorescent assays are
very diverse providing the most sensitive and robust methods for observing biological …

Non-Smad signaling pathways

Y Mu, SK Gudey, M Landström - Cell and tissue research, 2012 - Springer
Transforming growth factor-beta (TGFβ) is a key regulator of cell fate during embryogenesis
and has also emerged as a potent driver of the epithelial-mesenchymal transition during …