Anemia of inflammation (AI), also known as anemia of chronic disease (ACD), is regarded
as the most frequent anemia in hospitalized and chronically ill patients. It is prevalent in …

Once thought of exclusively as damaging molecules, reactive oxygen species (ROS) are
becoming increasingly appreciated for the role they play in cellular signaling through redox …

Anaemia and iron deficiency (ID) are frequent complications in patients with solid tumours or
haematological malignancies, particularly in patients treated with chemotherapeutic agents …

A classic physiologic response to systemic hypoxia is the increase in red blood cell
production. Hypoxia-inducible factors (HIFs) orchestrate this response by inducing cell-type …

Human erythropoietin (Epo) is a 30.4 kDa glycoprotein hormone composed of a single 165
amino acid residues chain to which four glycans are attached. The kidneys are the primary …

The kidney is a highly sensitive oxygen sensor and plays a central role in mediating the
hypoxic induction of red blood cell production. Efforts to understand the molecular basis of …

Background Anaemia associated with cancer and cancer therapy is an important clinical
factor in the treatment of malignant diseases. Therapeutic alternatives are recombinant …

In its classic hormonal role, erythropoietin (EPO) is produced by the kidney and regulates
the number of erythrocytes within the circulation to provide adequate tissue oxygenation …

Abstract Ethnopharmacological relevance Danggui buxue Decoction (DBD) has been
frequently used to treat with blood deficiency, which consisted of Danggui (DG) and Huangqi …

Erythropoietin (EPO), the main hemopoietic hormone synthesized by the kidney as well as
by the liver in fetal life, is implicated in mammalian erythropoiesis. Production and secretion …