Understanding the structure, functionalities and biology of functional amyloids is an issue of
emerging interest. Inclusion bodies, namely protein clusters formed in recombinant bacteria …

The formation of inclusion bodies (IBs) constitute a frequent event during the production of
heterologous proteins in bacterial hosts. Although the mechanisms leading to their formation …

In the last decades, the understanding of inclusion body biology and consequently, of their
properties and potential biotechnological applications have dramatically changed …

Background Bacterial inclusion bodies are submicron protein clusters usually found in
recombinant bacteria that have been traditionally considered as undesirable products from …

Inclusion bodies are insoluble protein aggregates usually found in recombinant bacteria
when they are forced to produce heterologous protein species. These particles are formed …

Slow protein release from amyloidal materials is a molecular platform used by nature to
control protein hormone secretion in the endocrine system. The molecular mechanics of the …

Developing time‐sustained drug delivery systems is a main goal in innovative medicines.
Inspired by the architecture of secretory granules from the mammalian endocrine system it …

An increasing number of both prokaryotic and eukaryotic cell types are being adapted as
platforms for recombinant protein production. The overproduction of proteins in such …

The progressive solving of the conformation of aggregated proteins and the conceptual
understanding of the biology of inclusion bodies in recombinant bacteria is providing …

Fourier transform infrared (FTIR) spectroscopy is a useful tool for the structural
characterization of insoluble protein assemblies, as it allows to obtain information on the …