The NLRP3 inflammasome is a multiprotein complex that plays a pivotal role in regulating
the innate immune system and inflammatory signaling. Upon activation by PAMPs and …

Abstract NOD-, LRR-, and pyrin domain-containing 3 (NLRP3) is a cytosolic innate immune
sensor of cellular stress signals, triggered by infection and sterile inflammation. Upon …

Inflammation has been implicated in atrial fibrillation (AF), a very common and clinically
significant cardiac rhythm disturbance, but its precise role remains poorly understood. Work …

Alzheimer's disease (AD) is a neurodegenerative disease associated with human aging.
Ten percent of individuals over 65 years have AD and its prevalence continues to rise with …

The immune system plays a critical role in shaping all facets of cancer, from the early
initiation stage through to metastatic disease and resistance to therapy. Our understanding …

The NLRP3 inflammasome is an intracellular multiprotein complex that plays an essential
role in the innate immune system by identifying and eliminating a plethora of endogenous …

Abstract Objective The CagA (cytotoxin-related gene A, CagA) protein is an important factor
for the pathogenicity of Helicobacter pylori (H. pylori). Although H. pylori has previously been …

Cerebrovascular diseases are pathological conditions involving impaired blood flow in the
brain, primarily including ischaemic stroke, intracranial haemorrhage, and subarachnoid …

Moraxella catarrhalis is an important human respiratory pathogen and a major causative
agent of otitis media and chronic obstructive pulmonary disease. Toll‐like receptors …

Evidence suggests that various innate immune system components are involved in
pathological inflammatory conditions. Among these components, the NLR family pyrin …