Sumoylation is an essential post-translational modification that is catalysed by a small
number of modifying enzymes but regulates thousands of target proteins in a dynamic …

Temporally and spatially controlled activation of the Aurora A kinase (AURKA) regulates
centrosome maturation, entry into mitosis, formation and function of the bipolar spindle, and …

Myc oncogenic transcription factors (c-Myc, N-Myc, and L-Myc) coordinate the control of cell
growth, division, and metabolism. In cancer, Myc overexpression is often associated with …

Introduction: Aurora proteins are serine/threonine kinases with critical functions during
mitosis. Aurora A, one of the members of this family, participates in crucial processes …

The Aurora kinases are essential regulators of mitosis in eukaryotes. In somatic cell
divisions of higher eukaryotes, the paralogs Aurora kinase A (AurA) and Aurora kinase B …

Like ubiquitin, the small ubiquitin-related modifier (SUMO) proteins can form oligomeric
“chains,” but the biological functions of these superstructures are not well understood. Here …

Aurora A is a serine/threonine kinase that contributes to the progression of mitosis by
inducing microtubule nucleation. Here we have identified an unexpected role for Aurora A …

Simple Summary Mono-ADP-ribosylating PARP enzymes are involved in the regulation of
several cellular pathways, including cell cycle. The mono-ADP-ribosyltransferase PARP10 is …

During mammalian meiosis, Polo-like kinase 1 (PLK1) is essential during cell cycle
progression. In oocyte maturation, PLK1 expression is well characterized but timing of …

Background Aurora kinases are essential enzymes for the control of cell cycle. The specific
role of aurora kinase A (AURKA) is the regulation of spindle assembly and stability by …