Epithelial to mesenchymal transition (EMT) contributes to tumor progression, cancer cell
invasion, and therapy resistance. EMT is regulated by transcription factors such as the …

Tissue transglutaminase (TG2) is a widely distributed multifunctional protein involved in a
broad range of cellular and metabolic functions carried out in a variety of cellular …

Pancreatic ductal adenocarcinoma (PDAC) is the most lethal common malignancy, with little
improvement in patient outcomes over the past decades. Recently, subtypes of pancreatic …

Although microbial transglutaminases (mTGs) were initially discovered to offset the cost of
producing mammalian transglutaminases for food applications, they have quickly become …

Abstract Purpose Cancer stem cells (CSCs) are highly tumorigenic cell types that reside
within specific areas of tumor microenvironment (TME), and are endowed with self-renewal …

Histone monoaminylation (ie., serotonylation and dopaminylation) is an emerging category
of epigenetic mark occurring on the fifth glutamine (Q5) residue of H3 N-terminal tail, which …

Primary open-angle glaucoma (POAG) is the second leading cause of blindness worldwide.
Elevated intraocular pressure (IOP) is a primary risk factor associated with POAG. Increased …

Rationale: Glioblastoma (GBM) is the most common and malignant primary brain tumor in
adults. Radiotherapy has long been an important treatment for GBM. Despite recent …

Recent studies indicate that cancer cells express elevated levels of type II transglutaminase
(TG2), and that expression is further highly enriched in cancer stem cells derived from these …

Several members of the Poly (ADP-ribose) polymerase (PARP) family are essential
regulators of genome integrity, actively prospected as drug targets for cancer therapy …