Streptococcus pneumoniae is an infectious pathogen responsible for millions of deaths
worldwide. Diseases caused by this bacterium are classified as pneumococcal diseases …

The extracellular secreted mucus and the cell surface glycocalyx prevent infection by the
vast numbers of microorganisms that live in the healthy gut. Mucin glycoproteins are the …

Much of the mortality attributed to influenza virus is due to secondary bacterial pneumonia,
particularly from Streptococcus pneumoniae. However, mechanisms underlying this …

Streptococcus pneumoniae remains a major cause of bacteremia, pneumonia, and otitis
media despite vaccines and effective antibiotics. The neuraminidase of S. pneumoniae …

High levels of copper are toxic and therefore bacteria must limit free intracellular levels to
prevent cellular damage. In this study, we show that a number of pneumococcal genes are …

Biofilm is a community of bacteria embedded in the extracellular matrix that accounts for
80% of bacterial infections. Biofilm enables bacterial cells to provide particular conditions …

Background Streptococcus pneumoniae, the pneumococcus, is the main etiological agent of
pneumonia. Pneumococcal infection is initiated by bacterial adherence to lung epithelial …

In Gram-positive bacteria, the transcriptional regulator CcpA is at the core of catabolite
control mechanisms. In the human pathogen Streptococcus pneumoniae, links between …

Asymptomatic colonization of the nasopharynx by Streptococcus pneumoniae precedes
pneumococcal disease, yet pneumococcal colonization factors remain poorly understood …

Streptococcus pneumoniae colonization of the human airway is an essential precursor for
disease; however, the mechanisms by which the bacterium establishes and maintains …