Probiotics are defined as live microorganisms that, when administered in adequate
amounts, confer a health benefit upon the host. At present, probiotics are gaining popularity …

Antibiotics and other agents that perturb the synthesis or integrity of the bacterial cell
envelope trigger compensatory stress responses. Focusing on Bacillus subtilis as a model …

Emerging resistance to currently used antibiotics is a global public health crisis. Because
most of the biosynthetic capacity within the bacterial kingdom has remained silent in …

The lipopeptide daptomycin is used as an antibiotic to treat severe infections with gram-
positive pathogens, such as methicillin resistant Staphylococcus aureus (MRSA) and drug …

Standardized and well-characterized genetic building blocks allow the convenient assembly
of novel genetic modules and devices, ensuring reusability of parts and reproducibility of …

Abstract d-Amino acid residues, found in countless peptides and natural products including
ribosomally synthesized and post-translationally modified peptides (RiPPs), are critical for …

Several metal-based carbon monoxide-releasing molecules (CORMs) are active CO donors
with established antibacterial activity. Among them, CORM conjugates with azole antibiotics …

Ribosomally synthesized peptides are built out of l-amino acids, whereas d-amino acids are
generally the hallmark of non-ribosomal synthetic processes. Here we show that the model …

Gram-positive bacterial infections present a major clinical challenge, with methicillin-and
vancomycin-resistant strains continuing to be a cause for concern. In recent years …

Bacitracin is a macrocyclic peptide antibiotic that is widely used as a topical treatment for
infections caused by gram-positive bacteria. Mechanistically, bacitracin targets bacteria by …