Oxidative stress, a term that describes the imbalance between oxidants and antioxidants,
leads to the disruption of redox signals and causes molecular damage. Increased oxidative …

Both inflammasomes and autophagy have important roles in the intracellular homeostasis,
inflammation, and pathology; the dysregulation of these processes is often associated with …

Background: Pathological cardiac hypertrophy is one of the leading causes of heart failure
with highly complicated pathogeneses. The E3 ligase TRIM16 (tripartite motif–containing …

To maintain proteostasis, cells must integrate information and activities that supervise
protein synthesis, protein folding, conformational stability, and also protein degradation …

Mitophagy/autophagy plays a protective role in various forms of liver damage, by renovating
cellular metabolism linking to sustain liver homeostasis. A characterized pathway for …

Macroautophagy/autophagy is a lysosome-dependent catabolic pathway for the degradation
of intracellular proteins and organelles. Autophagy dysfunction is related to many diseases …

Background Activation of the NLRP3 inflammasome promotes microglia to secrete
inflammatory cytokines and induce pyroptosis, leading to impaired phagocytic and …

Protein quality control (PQC) is pivotal for eukaryotic cells to eliminate misfolded proteins
and maintain cellular homeostasis. A decreased or increased capacity of PQC is associated …

Background Age‐related sarcopenia, characterized by reduced skeletal muscle mass and
function, significantly affects the health of the elderly individuals. Oxidative stress plays a …

Targeted degradation, having emerged as a powerful and promising strategy in drug
discovery in the past two decades, has provided a solution for many once undruggable …