AMPA receptors (AMPARs) are assemblies of four core subunits, GluA1–4, that mediate
most fast excitatory neurotransmission. The component subunits determine the functional …

AMPA receptors (AMPARs) are tetrameric ion channels that together with other ionotropic
glutamate receptors (iGluRs), the NMDA and kainate receptors, mediate a majority of …

Long-term potentiation (LTP) of synaptic strength occurs during learning and can last for
long periods, making it a probable mechanism for memory storage. LTP induction results in …

AMPA receptors (AMPARs) mediate the majority of fast excitatory synaptic transmission in
the brain. Dynamic changes in neuronal synaptic efficacy, termed synaptic plasticity, are …

The hippocampus is one of a group of remarkable structures embedded within the brain's
medial temporal lobe. Long known to be important for memory, it has been a prime focus of …

The ability to change behavior likely depends on the selective strengthening and weakening
of brain synapses. The cellular models of synaptic plasticity, long-term potentiation (LTP) …

Beta-amyloid (Aβ) depresses excitatory synapses by a poorly understood mechanism
requiring NMDA receptor (NMDAR) function. Here, we show that increased PSD-95, a major …

Glutamate receptors are the most abundant excitatory neurotransmitter receptors in the
brain, responsible for mediating the vast majority of excitatory transmission in neuronal …

Summary SynGAP is a Ras-GTPase activating protein highly enriched at excitatory
synapses in the brain. Previous studies have shown that CaMKII and the RAS-ERK pathway …

AMPA receptors (AMPARs) are fundamental elements in excitatory synaptic transmission
and synaptic plasticity in the CNS. Long term potentiation (LTP), a form of synaptic plasticity …