Metalloenzymes are central to a wide range of essential biological activities, including
nucleic acid modification, protein degradation, and many others. The role of metalloenzymes …

Reversible covalent bond formation under thermodynamic control adds reactivity to self-
assembled supramolecular systems, and is therefore an ideal tool to assess complexity of …

The pharmacological inhibition of general transcriptional regulators has the potential to
block growth through targeting multiple tumorigenic signalling pathways simultaneously …

2-Oxoglutarate (2OG) dependent oxygenases are ubiquitous iron enzymes that couple
substrate oxidation to the conversion of 2OG to succinate and carbon dioxide. In humans …

Dynamic combinatorial chemistry (DCC) has emerged as a powerful strategy to identify
ligands for biological targets given that it enables the target to direct the synthesis and …

The genetic changes leading to the development of human cancer are accompanied by
alterations in the structure and modification status of chromatin, which represent powerful …

Introducing novel strategies, concepts, and technologies that speed up drug discovery and
the drug development cycle is of great importance both in the highly competitive …

2-Oxoglutarate and ferrous iron-dependent oxygenases have emerged as an important
family of human enzymes that catalyse hydroxylations and related demethylation reactions …

Abstract The KDM4 subfamily H3K9 histone demethylases are epigenetic regulators that
control chromatin structure and gene expression by demethylating histone H3K9, H3K36 …

Members of the KDM5 (also known as JARID1) family are 2-oxoglutarate-and Fe2+-
dependent oxygenases that act as histone H3K4 demethylases, thereby regulating cell …