Calcium activation of ryanodine receptor channels—reconciling RyR gating models with tetrameric channel structure

I Zahradník, S Györke, A Zahradníková - The Journal of general …, 2005 - rupress.org
Despite its importance and abundance of experimental data, the molecular mechanism of
RyR2 activation by calcium is poorly understood. Recent experimental studies involving …

Calcium regulation of single ryanodine receptor channel gating analyzed using HMM/MCMC statistical methods

RA Rosales, M Fill, AL Escobar - The Journal of general physiology, 2004 - rupress.org
Type-II ryanodine receptor channels (RYRs) play a fundamental role in intracellular Ca2+
dynamics in heart. The processes of activation, inactivation, and regulation of these …